Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans

Jingwen Zhu, Qi Sun, Geng Zong, Yuan Si, Chen Liu, Qibin Qi, Xingwang Ye, Liang Sun, Hongguang Sheng, Huaixing Li, Xu Lin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Little is known about the associations of FADS1 genetic variants with circulating levels of PUFA and lipids in Asian populations who have a different dietary pattern and dyslipidemia prevalence compared with Western populations. In a population-based sample of 3,210 unrelated Han Chinese living in Beijing and Shanghai, we examined a FADS1 genetic variant, rs174550, in relation to blood PUFA and lipid levels. C-allele of rs174550 was signifi cantly associated with levels of erythrocyte PUFAs in upstream and downstream pathways of delta-5 desaturase (D5D) ( P≤0.003). Moreover, rs174550 C-allele was associated with a lower HDL cholesterol level ( P = 0.02) in total population and a higher triglyceride level ( P = 0.0002) in Beijing residents. Interestingly, erythrocyte levels of 18:2n-6 and 18:3n-3 modifi ed the effect of rs174550 on HDL cholesterol level: stronger associations between rs174550 C-allele and lower HDL cholesterol levels were exhibited when erythrocyte 18:2n-6 or 18:3n-3 level was low ( P for interaction = 0.02 and 0.03, respectively). These data suggested that FADS1 genetic variant was associated with circulating PUFA and lipid levels and that its effect on HDL cholesterol might depend on PUFA status in the Han Chinese population.

Original languageEnglish (US)
Pages (from-to)1477-1483
Number of pages7
JournalJournal of Lipid Research
Volume54
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Unsaturated Fatty Acids
HDL Cholesterol
Erythrocytes
Lipids
Population
Alleles
Dyslipidemias
Triglycerides
Blood
Beijing

Keywords

  • Delta-5 desaturase
  • Fatty acid desaturase 1
  • High density lipoprotein cholesterol
  • Triglycerides

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans. / Zhu, Jingwen; Sun, Qi; Zong, Geng; Si, Yuan; Liu, Chen; Qi, Qibin; Ye, Xingwang; Sun, Liang; Sheng, Hongguang; Li, Huaixing; Lin, Xu.

In: Journal of Lipid Research, Vol. 54, No. 5, 05.2013, p. 1477-1483.

Research output: Contribution to journalArticle

Zhu, Jingwen ; Sun, Qi ; Zong, Geng ; Si, Yuan ; Liu, Chen ; Qi, Qibin ; Ye, Xingwang ; Sun, Liang ; Sheng, Hongguang ; Li, Huaixing ; Lin, Xu. / Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans. In: Journal of Lipid Research. 2013 ; Vol. 54, No. 5. pp. 1477-1483.
@article{3812da8848db45458a641577d5ba7259,
title = "Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans",
abstract = "Little is known about the associations of FADS1 genetic variants with circulating levels of PUFA and lipids in Asian populations who have a different dietary pattern and dyslipidemia prevalence compared with Western populations. In a population-based sample of 3,210 unrelated Han Chinese living in Beijing and Shanghai, we examined a FADS1 genetic variant, rs174550, in relation to blood PUFA and lipid levels. C-allele of rs174550 was signifi cantly associated with levels of erythrocyte PUFAs in upstream and downstream pathways of delta-5 desaturase (D5D) ( P≤0.003). Moreover, rs174550 C-allele was associated with a lower HDL cholesterol level ( P = 0.02) in total population and a higher triglyceride level ( P = 0.0002) in Beijing residents. Interestingly, erythrocyte levels of 18:2n-6 and 18:3n-3 modifi ed the effect of rs174550 on HDL cholesterol level: stronger associations between rs174550 C-allele and lower HDL cholesterol levels were exhibited when erythrocyte 18:2n-6 or 18:3n-3 level was low ( P for interaction = 0.02 and 0.03, respectively). These data suggested that FADS1 genetic variant was associated with circulating PUFA and lipid levels and that its effect on HDL cholesterol might depend on PUFA status in the Han Chinese population.",
keywords = "Delta-5 desaturase, Fatty acid desaturase 1, High density lipoprotein cholesterol, Triglycerides",
author = "Jingwen Zhu and Qi Sun and Geng Zong and Yuan Si and Chen Liu and Qibin Qi and Xingwang Ye and Liang Sun and Hongguang Sheng and Huaixing Li and Xu Lin",
year = "2013",
month = "5",
doi = "10.1194/jlr.P027516",
language = "English (US)",
volume = "54",
pages = "1477--1483",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "5",

}

TY - JOUR

T1 - Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans

AU - Zhu, Jingwen

AU - Sun, Qi

AU - Zong, Geng

AU - Si, Yuan

AU - Liu, Chen

AU - Qi, Qibin

AU - Ye, Xingwang

AU - Sun, Liang

AU - Sheng, Hongguang

AU - Li, Huaixing

AU - Lin, Xu

PY - 2013/5

Y1 - 2013/5

N2 - Little is known about the associations of FADS1 genetic variants with circulating levels of PUFA and lipids in Asian populations who have a different dietary pattern and dyslipidemia prevalence compared with Western populations. In a population-based sample of 3,210 unrelated Han Chinese living in Beijing and Shanghai, we examined a FADS1 genetic variant, rs174550, in relation to blood PUFA and lipid levels. C-allele of rs174550 was signifi cantly associated with levels of erythrocyte PUFAs in upstream and downstream pathways of delta-5 desaturase (D5D) ( P≤0.003). Moreover, rs174550 C-allele was associated with a lower HDL cholesterol level ( P = 0.02) in total population and a higher triglyceride level ( P = 0.0002) in Beijing residents. Interestingly, erythrocyte levels of 18:2n-6 and 18:3n-3 modifi ed the effect of rs174550 on HDL cholesterol level: stronger associations between rs174550 C-allele and lower HDL cholesterol levels were exhibited when erythrocyte 18:2n-6 or 18:3n-3 level was low ( P for interaction = 0.02 and 0.03, respectively). These data suggested that FADS1 genetic variant was associated with circulating PUFA and lipid levels and that its effect on HDL cholesterol might depend on PUFA status in the Han Chinese population.

AB - Little is known about the associations of FADS1 genetic variants with circulating levels of PUFA and lipids in Asian populations who have a different dietary pattern and dyslipidemia prevalence compared with Western populations. In a population-based sample of 3,210 unrelated Han Chinese living in Beijing and Shanghai, we examined a FADS1 genetic variant, rs174550, in relation to blood PUFA and lipid levels. C-allele of rs174550 was signifi cantly associated with levels of erythrocyte PUFAs in upstream and downstream pathways of delta-5 desaturase (D5D) ( P≤0.003). Moreover, rs174550 C-allele was associated with a lower HDL cholesterol level ( P = 0.02) in total population and a higher triglyceride level ( P = 0.0002) in Beijing residents. Interestingly, erythrocyte levels of 18:2n-6 and 18:3n-3 modifi ed the effect of rs174550 on HDL cholesterol level: stronger associations between rs174550 C-allele and lower HDL cholesterol levels were exhibited when erythrocyte 18:2n-6 or 18:3n-3 level was low ( P for interaction = 0.02 and 0.03, respectively). These data suggested that FADS1 genetic variant was associated with circulating PUFA and lipid levels and that its effect on HDL cholesterol might depend on PUFA status in the Han Chinese population.

KW - Delta-5 desaturase

KW - Fatty acid desaturase 1

KW - High density lipoprotein cholesterol

KW - Triglycerides

UR - http://www.scopus.com/inward/record.url?scp=84876791563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876791563&partnerID=8YFLogxK

U2 - 10.1194/jlr.P027516

DO - 10.1194/jlr.P027516

M3 - Article

VL - 54

SP - 1477

EP - 1483

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 5

ER -