Integration of nutritional and stress signaling pathways by Maf1

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Repression of RNA polymerase III transcription under many conditions requires Maf1, a yeast protein with close sequence homologs in all eukaryotes. Three recent studies have identified key aspects of Maf1 regulation, which suggest that Maf1 integrates the responses from convergent nutritional and stress signaling pathways. These new findings indicate that the opposing actions of protein kinase A and protein phosphatase 2A alter the phosphorylation state of Maf1 and thereby regulate its localization and repressing activity.

Original languageEnglish (US)
Pages (from-to)51-53
Number of pages3
JournalTrends in Biochemical Sciences
Volume32
Issue number2
DOIs
StatePublished - Feb 2007

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RNA Polymerase III
Protein Phosphatase 2
Phosphorylation
Fungal Proteins
Transcription
Sequence Homology
Cyclic AMP-Dependent Protein Kinases
Eukaryota

ASJC Scopus subject areas

  • Biochemistry

Cite this

Integration of nutritional and stress signaling pathways by Maf1. / Willis, Ian M.; Moir, Robyn D.

In: Trends in Biochemical Sciences, Vol. 32, No. 2, 02.2007, p. 51-53.

Research output: Contribution to journalArticle

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