Integration of cancer genomics with treatment selection: From the genome to predictive biomarkers

Thomas J. Ow, Vlad C. Sandulache, Heath D. Skinner, Jeffrey N. Myers

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The field of cancer genomics is rapidly advancing as new technology provides detailed genetic and epigenetic profiling of human cancers. The amount of new data available describing the genetic make-up of tumors is paralleled by rapid advances in drug discovery and molecular therapy currently under investigation to treat these diseases. This review summarizes the challenges and approaches associated with the integration of genomic data into the development of new biomarkers in the management of cancer.

Original languageEnglish (US)
Pages (from-to)3914-3928
Number of pages15
JournalCancer
Volume119
Issue number22
DOIs
StatePublished - Nov 15 2013

Keywords

  • biologic markers
  • clinical trials as topic
  • computational biology
  • genomics
  • molecular targeted therapy
  • neoplasms
  • systems biology
  • therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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