TY - JOUR
T1 - Integrating risk profiles for disease progression in the treatment choice for patients with lower urinary tract symptoms/benign prostatic hyperplasia
T2 - A combined analysis of external evidence and clinical expertise
AU - Speakman, M.
AU - Batista, J.
AU - Berges, R.
AU - Chartier-Kastler, E.
AU - Conti, G.
AU - Desgrandchamps, F.
AU - Dreikorn, K.
AU - Lowe, F.
AU - O'Leary, M.
AU - Perez, M.
AU - Trachtenberg, J.
AU - Tubaro, A.
AU - Meesen, B.
AU - Smets, L.
AU - Stoevelaar, H.
N1 - Funding Information:
This study was supported by an unrestricted educational grant from Boehringer Ingelheim GmbH.
PY - 2005/12
Y1 - 2005/12
N2 - The RAND appropriateness method was used to explore the relevance of risk factors for disease progression in the treatment choice for patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). A total of, 12 international experts assessed the appropriateness of various treatments for 243 risk profiles. Highest appropriateness rates were found for α1-adrenoceptor antagonists (68% of profiles) and combination therapy (46%). A large prostate volume was the dominant argument in favour of 5α-reductase inhibitors and combination therapy, but was irrelevant for the choice of surgery. Considerable postvoid residual, severe symptoms and poor maximum flow rate were the most important factors in favour of surgery.
AB - The RAND appropriateness method was used to explore the relevance of risk factors for disease progression in the treatment choice for patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). A total of, 12 international experts assessed the appropriateness of various treatments for 243 risk profiles. Highest appropriateness rates were found for α1-adrenoceptor antagonists (68% of profiles) and combination therapy (46%). A large prostate volume was the dominant argument in favour of 5α-reductase inhibitors and combination therapy, but was irrelevant for the choice of surgery. Considerable postvoid residual, severe symptoms and poor maximum flow rate were the most important factors in favour of surgery.
KW - Benign prostatic hyperplasia
KW - Evidence-based medicine
KW - Lower urinary tract symptoms
KW - RAND appropriateness method
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=30544436072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30544436072&partnerID=8YFLogxK
U2 - 10.1038/sj.pcan.4500827
DO - 10.1038/sj.pcan.4500827
M3 - Article
C2 - 16130013
AN - SCOPUS:30544436072
SN - 1365-7852
VL - 8
SP - 369
EP - 374
JO - Prostate Cancer and Prostatic Diseases
JF - Prostate Cancer and Prostatic Diseases
IS - 4
ER -
