Integral radiation dose to normal structures with conformal external beam radiation

Hidefumi Aoyama, David Clark Westerly, Thomas Rockwell MacKie, Gustavo H. Olivera, Søren M. Bentzen, Rakesh R. Patel, Hazim Jaradat, Wolfgang A. Tome, Mark A. Ritter, Minesh P. Mehta

Research output: Contribution to journalArticle

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Abstract

Background: This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer. Methods and Materials: Twenty-five radiation treatment plans including IMRT using a conventional linac with both 6 MV (6MV-IMRT) and 20 MV (20MV-IMRT), as well as three-dimensional conformal radiotherapy (3DCRT) using 6 MV (6MV-3DCRT) and 20 MV (20MV-3DCRT) and IMRT using tomotherapy (6MV) (Tomo-IMRT), were created for 5 patients with localized prostate cancer. The ID (mean dose × tissue volume) received by normal tissue (NTID) was calculated from dose-volume histograms. Results: The 6MV-IMRT resulted in 5.0% lower NTID than 6MV-3DCRT; 20 MV beam plans resulted in 7.7%-11.2% lower NTID than 6MV-3DCRT. Tomo-IMRT NTID was comparable to 6MV-IMRT. Compared with 6MV-3DCRT, 6MV-IMRT reduced IDs to the rectal wall and penile bulb by 6.1% and 2.7%, respectively. Tomo-IMRT further reduced these IDs by 11.9% and 16.5%, respectively. The 20 MV did not reduce IDs to those structures. Conclusions: The difference in NTID between 3DCRT and IMRT is small. The 20 MV plans somewhat reduced NTID compared with 6 MV plans. The advantage of tomotherapy over conventional IMRT and 3DCRT for localized prostate cancer was demonstrated in regard to dose sparing of rectal wall and penile bulb while slightly decreasing NTID as compared with 6MV-3DCRT.

Original languageEnglish (US)
Pages (from-to)962-967
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume64
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

Intensity-Modulated Radiotherapy
radiation therapy
Radiation
dosage
radiation
Prostatic Neoplasms
bulbs
cancer
Conformal Radiotherapy
histograms

Keywords

  • IMRT
  • Integral dose
  • Prostrate cancer
  • Radiation
  • Tomotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Aoyama, H., Westerly, D. C., MacKie, T. R., Olivera, G. H., Bentzen, S. M., Patel, R. R., ... Mehta, M. P. (2006). Integral radiation dose to normal structures with conformal external beam radiation. International Journal of Radiation Oncology Biology Physics, 64(3), 962-967. https://doi.org/10.1016/j.ijrobp.2005.11.005

Integral radiation dose to normal structures with conformal external beam radiation. / Aoyama, Hidefumi; Westerly, David Clark; MacKie, Thomas Rockwell; Olivera, Gustavo H.; Bentzen, Søren M.; Patel, Rakesh R.; Jaradat, Hazim; Tome, Wolfgang A.; Ritter, Mark A.; Mehta, Minesh P.

In: International Journal of Radiation Oncology Biology Physics, Vol. 64, No. 3, 01.03.2006, p. 962-967.

Research output: Contribution to journalArticle

Aoyama, H, Westerly, DC, MacKie, TR, Olivera, GH, Bentzen, SM, Patel, RR, Jaradat, H, Tome, WA, Ritter, MA & Mehta, MP 2006, 'Integral radiation dose to normal structures with conformal external beam radiation', International Journal of Radiation Oncology Biology Physics, vol. 64, no. 3, pp. 962-967. https://doi.org/10.1016/j.ijrobp.2005.11.005
Aoyama, Hidefumi ; Westerly, David Clark ; MacKie, Thomas Rockwell ; Olivera, Gustavo H. ; Bentzen, Søren M. ; Patel, Rakesh R. ; Jaradat, Hazim ; Tome, Wolfgang A. ; Ritter, Mark A. ; Mehta, Minesh P. / Integral radiation dose to normal structures with conformal external beam radiation. In: International Journal of Radiation Oncology Biology Physics. 2006 ; Vol. 64, No. 3. pp. 962-967.
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abstract = "Background: This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer. Methods and Materials: Twenty-five radiation treatment plans including IMRT using a conventional linac with both 6 MV (6MV-IMRT) and 20 MV (20MV-IMRT), as well as three-dimensional conformal radiotherapy (3DCRT) using 6 MV (6MV-3DCRT) and 20 MV (20MV-3DCRT) and IMRT using tomotherapy (6MV) (Tomo-IMRT), were created for 5 patients with localized prostate cancer. The ID (mean dose × tissue volume) received by normal tissue (NTID) was calculated from dose-volume histograms. Results: The 6MV-IMRT resulted in 5.0{\%} lower NTID than 6MV-3DCRT; 20 MV beam plans resulted in 7.7{\%}-11.2{\%} lower NTID than 6MV-3DCRT. Tomo-IMRT NTID was comparable to 6MV-IMRT. Compared with 6MV-3DCRT, 6MV-IMRT reduced IDs to the rectal wall and penile bulb by 6.1{\%} and 2.7{\%}, respectively. Tomo-IMRT further reduced these IDs by 11.9{\%} and 16.5{\%}, respectively. The 20 MV did not reduce IDs to those structures. Conclusions: The difference in NTID between 3DCRT and IMRT is small. The 20 MV plans somewhat reduced NTID compared with 6 MV plans. The advantage of tomotherapy over conventional IMRT and 3DCRT for localized prostate cancer was demonstrated in regard to dose sparing of rectal wall and penile bulb while slightly decreasing NTID as compared with 6MV-3DCRT.",
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AU - Westerly, David Clark

AU - MacKie, Thomas Rockwell

AU - Olivera, Gustavo H.

AU - Bentzen, Søren M.

AU - Patel, Rakesh R.

AU - Jaradat, Hazim

AU - Tome, Wolfgang A.

AU - Ritter, Mark A.

AU - Mehta, Minesh P.

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AB - Background: This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer. Methods and Materials: Twenty-five radiation treatment plans including IMRT using a conventional linac with both 6 MV (6MV-IMRT) and 20 MV (20MV-IMRT), as well as three-dimensional conformal radiotherapy (3DCRT) using 6 MV (6MV-3DCRT) and 20 MV (20MV-3DCRT) and IMRT using tomotherapy (6MV) (Tomo-IMRT), were created for 5 patients with localized prostate cancer. The ID (mean dose × tissue volume) received by normal tissue (NTID) was calculated from dose-volume histograms. Results: The 6MV-IMRT resulted in 5.0% lower NTID than 6MV-3DCRT; 20 MV beam plans resulted in 7.7%-11.2% lower NTID than 6MV-3DCRT. Tomo-IMRT NTID was comparable to 6MV-IMRT. Compared with 6MV-3DCRT, 6MV-IMRT reduced IDs to the rectal wall and penile bulb by 6.1% and 2.7%, respectively. Tomo-IMRT further reduced these IDs by 11.9% and 16.5%, respectively. The 20 MV did not reduce IDs to those structures. Conclusions: The difference in NTID between 3DCRT and IMRT is small. The 20 MV plans somewhat reduced NTID compared with 6 MV plans. The advantage of tomotherapy over conventional IMRT and 3DCRT for localized prostate cancer was demonstrated in regard to dose sparing of rectal wall and penile bulb while slightly decreasing NTID as compared with 6MV-3DCRT.

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KW - Prostrate cancer

KW - Radiation

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