Intakes of vitamins A, C and E and folate and multivitamins and lung cancer

A pooled analysis of 8 prospective studies

Eunyoung Cho, David J. Hunter, Donna Spiegelman, Demetrius Albanes, W. Lawrence Beeson, Piet A. Van Den Brandt, Graham A. Colditz, Diane Feskanich, Aaron R. Folsom, Gary E. Fraser, Jo L. Freudenheim, Edward Giovannucci, R. Alexandra Goldbohm, Saxon Graham, Anthony B. Miller, Thomas E. Rohan, Thomas A. Sellers, Jarmo Virtamo, Walter C. Willett, Stephanie A. Smith-Warner

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Abstract

Intakes of vitamins A, C and E and folate have been hypothesized to reduce lung cancer risk. We examined these associations in a pooled analysis of the primary data from 8 prospective studies from North America and Europe. Baseline vitamin intake was assessed using a validated food-frequency questionnaire, in each study. We calculated study-specific associations and pooled them using a random-effects model. During follow-up of 430,281 persons over a maximum of 6-16 years in the studies, 3,206 incident lung cancer cases were documented. Vitamin intakes were inversely associated with lung cancer risk in age-adjusted analyses; the associations were greatly attenuated after adjusting for smoking and other risk factors for lung cancer. The pooled multivariate relative risks, comparing the highest vs. lowest quintile of intake from food-only, were 0.96 (95% confidence interval (CI) 0.83-1.11) for vitamin A, 0.80 (95% CI 0.71-0.91) for vitamin C, 0.86 (95% CI 0.76-0.99) for vitamin E and 0.88 (95% CI 0.74-1.04) for folate. The association with vitamin C was not independent of our previously reported inverse association with β-cryptoxanthin. Further, vitamin intakes from foods plus supplements were not associated with a reduced risk of lung cancer in multivariate analyses, and use of multivitamins and specific vitamin supplements was not significantly associated with lung cancer risk. The results generally did not differ across studies or by sex, smoking habits and lung cancer cell type. In conclusion, these data do not support the hypothesis that intakes of vitamins A, C and E and folate reduce lung cancer risk.

Original languageEnglish (US)
Pages (from-to)970-978
Number of pages9
JournalInternational Journal of Cancer
Volume118
Issue number4
DOIs
StatePublished - Feb 15 2006

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Vitamin A
Vitamin E
Folic Acid
Ascorbic Acid
Lung Neoplasms
Prospective Studies
Vitamins
Confidence Intervals
Smoking
Dietary Supplements
North America
Habits
Multivariate Analysis
Eating
Food

Keywords

  • Folic acid
  • Lung neoplasms
  • Vitamin A
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cho, E., Hunter, D. J., Spiegelman, D., Albanes, D., Beeson, W. L., Van Den Brandt, P. A., ... Smith-Warner, S. A. (2006). Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: A pooled analysis of 8 prospective studies. International Journal of Cancer, 118(4), 970-978. https://doi.org/10.1002/ijc.21441

Intakes of vitamins A, C and E and folate and multivitamins and lung cancer : A pooled analysis of 8 prospective studies. / Cho, Eunyoung; Hunter, David J.; Spiegelman, Donna; Albanes, Demetrius; Beeson, W. Lawrence; Van Den Brandt, Piet A.; Colditz, Graham A.; Feskanich, Diane; Folsom, Aaron R.; Fraser, Gary E.; Freudenheim, Jo L.; Giovannucci, Edward; Goldbohm, R. Alexandra; Graham, Saxon; Miller, Anthony B.; Rohan, Thomas E.; Sellers, Thomas A.; Virtamo, Jarmo; Willett, Walter C.; Smith-Warner, Stephanie A.

In: International Journal of Cancer, Vol. 118, No. 4, 15.02.2006, p. 970-978.

Research output: Contribution to journalArticle

Cho, E, Hunter, DJ, Spiegelman, D, Albanes, D, Beeson, WL, Van Den Brandt, PA, Colditz, GA, Feskanich, D, Folsom, AR, Fraser, GE, Freudenheim, JL, Giovannucci, E, Goldbohm, RA, Graham, S, Miller, AB, Rohan, TE, Sellers, TA, Virtamo, J, Willett, WC & Smith-Warner, SA 2006, 'Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: A pooled analysis of 8 prospective studies', International Journal of Cancer, vol. 118, no. 4, pp. 970-978. https://doi.org/10.1002/ijc.21441
Cho, Eunyoung ; Hunter, David J. ; Spiegelman, Donna ; Albanes, Demetrius ; Beeson, W. Lawrence ; Van Den Brandt, Piet A. ; Colditz, Graham A. ; Feskanich, Diane ; Folsom, Aaron R. ; Fraser, Gary E. ; Freudenheim, Jo L. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Graham, Saxon ; Miller, Anthony B. ; Rohan, Thomas E. ; Sellers, Thomas A. ; Virtamo, Jarmo ; Willett, Walter C. ; Smith-Warner, Stephanie A. / Intakes of vitamins A, C and E and folate and multivitamins and lung cancer : A pooled analysis of 8 prospective studies. In: International Journal of Cancer. 2006 ; Vol. 118, No. 4. pp. 970-978.
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