Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study

Geoffrey C. Kabat, Yikyung Park, Albert R. Hollenbeck, Arthur Schatzkin, Thomas E. Rohan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Fruits and vegetables contain a wide variety of phytochemicals which may have anti-carcinogenic effects. Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association. Materials and methods: We used data from the NIH-AARP Diet and Health Study to assess the association of fruit and vegetable consumption, as well as intake of specific botanical groupings of fruits and vegetables, with endometrial cancer risk among 112,088 women who completed a food-frequency questionnaire at baseline, in 1995-1996. During 8 years of follow-up 1142 incident cases of endometrial cancer were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: After adjustment for covariates, HRs for the highest compared to the lowest quintile of total fruit and total vegetable intake were 1.30 (95% CI 1.04-1.61, P for trend 0.05) and 1.09 (95% CI 0.90-1.33, P for trend 0.55), respectively. No inverse associations were observed for intake of any of 13 botanical groupings of fruits and vegetables. Conclusions: Results from this large prospective study do not support a protective role of a high intake of fruits or vegetables on the risk of endometrial cancer in older women.

Original languageEnglish (US)
Pages (from-to)568-573
Number of pages6
JournalCancer Epidemiology
Volume34
Issue number5
DOIs
StatePublished - Oct 2010

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Endometrial Neoplasms
Vegetables
Fruit
Diet
Health
Confidence Intervals
Anticarcinogenic Agents
Phytochemicals
Proportional Hazards Models
Case-Control Studies
Cohort Studies
Prospective Studies
Food

Keywords

  • Cohort studies
  • Endometrial cancer
  • Fruit and vegetable intake
  • Phytochemicals

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

Cite this

Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. / Kabat, Geoffrey C.; Park, Yikyung; Hollenbeck, Albert R.; Schatzkin, Arthur; Rohan, Thomas E.

In: Cancer Epidemiology, Vol. 34, No. 5, 10.2010, p. 568-573.

Research output: Contribution to journalArticle

Kabat, Geoffrey C. ; Park, Yikyung ; Hollenbeck, Albert R. ; Schatzkin, Arthur ; Rohan, Thomas E. / Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. In: Cancer Epidemiology. 2010 ; Vol. 34, No. 5. pp. 568-573.
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