Abstract
Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously. Objective: Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease. Design and Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health. Patient and Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor. Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative. Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1123-1128 |
| Number of pages | 6 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 93 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. / Lodish, Maya B.; Powell, Anathea C.; Abu-Asab, Mones; Cochran, Craig; Lenz, Petra; Libutti, Steven K.; Pingpank, James F.; Tsokos, Maria; Gorden, Phillip.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 4, 04.2008, p. 1123-1128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor
AU - Lodish, Maya B.
AU - Powell, Anathea C.
AU - Abu-Asab, Mones
AU - Cochran, Craig
AU - Lenz, Petra
AU - Libutti, Steven K.
AU - Pingpank, James F.
AU - Tsokos, Maria
AU - Gorden, Phillip
PY - 2008/4
Y1 - 2008/4
N2 - Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously. Objective: Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease. Design and Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health. Patient and Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor. Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative. Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.
AB - Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously. Objective: Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease. Design and Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health. Patient and Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor. Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative. Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.
UR - http://www.scopus.com/inward/record.url?scp=42049092087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42049092087&partnerID=8YFLogxK
U2 - 10.1210/jc.2007-2449
DO - 10.1210/jc.2007-2449
M3 - Article
C2 - 18252785
AN - SCOPUS:42049092087
VL - 93
SP - 1123
EP - 1128
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -