Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor

Maya B. Lodish, Anathea C. Powell, Mones Abu-Asab, Craig Cochran, Petra Lenz, Steven K. Libutti, James F. Pingpank, Maria Tsokos, Phillip Gorden

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously. Objective: Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease. Design and Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health. Patient and Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor. Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative. Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.

Original languageEnglish (US)
Pages (from-to)1123-1128
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

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Gastrinoma
Insulinoma
Neuroendocrine Tumors
Tumors
Hypoglycemic Agents
Peptic Ulcer
Insulin
Gastrins
National Institutes of Health (U.S.)
Hypoglycemia
Health
Ulcer
Diarrhea
Neoplasms
Research

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Lodish, M. B., Powell, A. C., Abu-Asab, M., Cochran, C., Lenz, P., Libutti, S. K., ... Gorden, P. (2008). Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. Journal of Clinical Endocrinology and Metabolism, 93(4), 1123-1128. https://doi.org/10.1210/jc.2007-2449

Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. / Lodish, Maya B.; Powell, Anathea C.; Abu-Asab, Mones; Cochran, Craig; Lenz, Petra; Libutti, Steven K.; Pingpank, James F.; Tsokos, Maria; Gorden, Phillip.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 4, 04.2008, p. 1123-1128.

Research output: Contribution to journalArticle

Lodish, MB, Powell, AC, Abu-Asab, M, Cochran, C, Lenz, P, Libutti, SK, Pingpank, JF, Tsokos, M & Gorden, P 2008, 'Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor', Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 4, pp. 1123-1128. https://doi.org/10.1210/jc.2007-2449
Lodish, Maya B. ; Powell, Anathea C. ; Abu-Asab, Mones ; Cochran, Craig ; Lenz, Petra ; Libutti, Steven K. ; Pingpank, James F. ; Tsokos, Maria ; Gorden, Phillip. / Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. In: Journal of Clinical Endocrinology and Metabolism. 2008 ; Vol. 93, No. 4. pp. 1123-1128.
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