Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor

Maya B. Lodish, Anathea C. Powell, Mones Abu-Asab, Craig Cochran, Petra Lenz, Steven K. Libutti, James F. Pingpank, Maria Tsokos, Phillip Gorden

Research output: Contribution to journalArticle

10 Scopus citations


Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously. Objective: Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease. Design and Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health. Patient and Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor. Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative. Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.

Original languageEnglish (US)
Pages (from-to)1123-1128
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Apr 2008


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lodish, M. B., Powell, A. C., Abu-Asab, M., Cochran, C., Lenz, P., Libutti, S. K., Pingpank, J. F., Tsokos, M., & Gorden, P. (2008). Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. Journal of Clinical Endocrinology and Metabolism, 93(4), 1123-1128.