Insulin signaling pathways in time and space

Alan R. Saltiel, Jeffrey E. Pessin

Research output: Contribution to journalReview articlepeer-review

501 Scopus citations


Despite remarkable progress in dissecting the signaling pathways that are crucial for the metabolic effects of insulin, the molecular basis for the specificity of its cellular actions is not fully understood. One clue might lie in the spatial and temporal aspects of signaling. Recent evidence suggests that signaling molecules and pathways are localized to discrete compartments in cells by specific protein interactions. Also, the rapid termination of tyrosine or lipid phosphorylation by phosphatases or serine kinases might tightly control the strength of a signaling pathway, thus determining its effect on growth, differentiation and metabolism.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalTrends in Cell Biology
Issue number2
StatePublished - Feb 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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