Insulin regulation of the Ras activation/inactivation cycle

Brian P. Ceresa, Jeffrey E. Pessin

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

In addition to mediating a number of metabolic functions, insulin also uses mitogenic pathways to maintain cellular homeostasis. Many of these mitogenic responses are mediated by signals through the small molecular weight guanine nucleotide binding protein, Ras. In the last decade, great progress has been made in understanding the molecular mechanisms which regulate the insulin mediated conversion of Ras from its inactive, GDP-bound state, to the activated GTP-bound form. More recently, it has been appreciated that insulin also regulates the inactivation of this pathway, namely by uncoupling the protein complexes whose formation is required for Ras activation. This review addresses molecular mechanism which both positively and negatively regulate this mitogenic signalling pathway.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume182
Issue number1-2
DOIs
StatePublished - May 5 1998
Externally publishedYes

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Keywords

  • IRS-1
  • Insulin
  • MAP kinase
  • Ras
  • SOS
  • Shc

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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