TY - JOUR
T1 - Insulin receptor substrate 1 and 2 (IRS1 and IRS2)
T2 - What a tangled web we weave
AU - Watersand, Steven B.
AU - Pessin, Jeffrey E.
PY - 1996/1
Y1 - 1996/1
N2 - The insulin receptor is a transmembrane tyrosine kinase that is essential for mediating multiple intracellular signalling cascades that lean ultimately to the biological actions of insulin. Tyrosine phosphorylation of the cytosolic proteins insulin receptor substrate 1 and 2 (IRS1 and IRS2) produces protein 'scaffolding' for the assembly of effector proteins containing Src homology 2 (SH2) domains, thereby generating multisubunit signalling complexes. Although IRS1 was originally isolated as a specific insulin receptor substrate, both IRS1 and IRS2 appear to play a broader role, functioning also as proximal substrates in growth hormone and cytokine receptor signalling. Current data establish IRS1 and IRS2 as critical effecters integrating various cell-type-specific signals into distinct, but overlapping, biological responses.
AB - The insulin receptor is a transmembrane tyrosine kinase that is essential for mediating multiple intracellular signalling cascades that lean ultimately to the biological actions of insulin. Tyrosine phosphorylation of the cytosolic proteins insulin receptor substrate 1 and 2 (IRS1 and IRS2) produces protein 'scaffolding' for the assembly of effector proteins containing Src homology 2 (SH2) domains, thereby generating multisubunit signalling complexes. Although IRS1 was originally isolated as a specific insulin receptor substrate, both IRS1 and IRS2 appear to play a broader role, functioning also as proximal substrates in growth hormone and cytokine receptor signalling. Current data establish IRS1 and IRS2 as critical effecters integrating various cell-type-specific signals into distinct, but overlapping, biological responses.
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U2 - 10.1016/0962-8924(96)81024-5
DO - 10.1016/0962-8924(96)81024-5
M3 - Comment/debate
C2 - 15157524
AN - SCOPUS:0343027288
SN - 0962-8924
VL - 6
SP - 1
EP - 4
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 1
ER -