Insulin receptor substrate 1 and 2 (IRS1 and IRS2)

What a tangled web we weave

Steven B. Watersand, Jeffrey E. Pessin

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The insulin receptor is a transmembrane tyrosine kinase that is essential for mediating multiple intracellular signalling cascades that lean ultimately to the biological actions of insulin. Tyrosine phosphorylation of the cytosolic proteins insulin receptor substrate 1 and 2 (IRS1 and IRS2) produces protein 'scaffolding' for the assembly of effector proteins containing Src homology 2 (SH2) domains, thereby generating multisubunit signalling complexes. Although IRS1 was originally isolated as a specific insulin receptor substrate, both IRS1 and IRS2 appear to play a broader role, functioning also as proximal substrates in growth hormone and cytokine receptor signalling. Current data establish IRS1 and IRS2 as critical effecters integrating various cell-type-specific signals into distinct, but overlapping, biological responses.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalTrends in Cell Biology
Volume6
Issue number1
DOIs
StatePublished - Jan 1996
Externally publishedYes

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Insulin Receptor Substrate Proteins
Insulin Receptor
Somatotropin Receptors
Cytokine Receptors
src Homology Domains
Protein-Tyrosine Kinases
Tyrosine
Proteins
Phosphorylation
Insulin

ASJC Scopus subject areas

  • Cell Biology

Cite this

Insulin receptor substrate 1 and 2 (IRS1 and IRS2) : What a tangled web we weave. / Watersand, Steven B.; Pessin, Jeffrey E.

In: Trends in Cell Biology, Vol. 6, No. 1, 01.1996, p. 1-4.

Research output: Contribution to journalArticle

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