Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals

Hyeon Sook Suh, Yungtai Lo, Namjong Choi, Scott Letendre, Sunhee C. Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Clinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown. Methods: We measured the levels of IGF1, IGF2, IGFBP1, IGFBP2, and IGF2 receptor (IGF2R) in matching plasma and cerebrospinal fluid (CSF) samples of 107 HIV+ individuals from CNS HIV Antiretroviral Therapy Effects Research (CHARTER) and analyzed their associations with demographic and disease characteristics, as well as levels of several soluble inflammatory mediators (TNFα, IL-6, IL-10, IL-17, IP-10, MCP-1, and progranulin). We also determined whether IGF1 or IGF2 deficiency is associated with HIV-associated neurocognitive disorder (HAND) and whether the levels of soluble IGF2R (an IGF scavenging receptor, which we also have found to be a cofactor for HIV infection in vitro) correlate with HIV viral load (VL). Results: There was a positive correlation between the levels of IGF-binding proteins (IGFBPs) and those of inflammatory mediators: between plasma IGFBP1 and IL-17 (α coefficient 0.28, P=0.009), plasma IGFBP2 and IL-6 (α coefficient 0.209, P=0.021), CSF IGFBP1 and TNFα (α coefficient 0.394, P

Original languageEnglish (US)
Article number72
JournalJournal of Neuroinflammation
Volume12
Issue number1
DOIs
StatePublished - Apr 15 2015

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Somatomedins
Cerebrospinal Fluid
Blood Proteins
HIV
Interleukin-17
Interleukin-6
Insulin-Like Growth Factor Binding Proteins
Growth Factor Receptors
Insulin Receptor
Viral Load
Interleukin-10
HIV Infections
Demography
Research
Proteins

Keywords

  • Biomarker
  • Charter
  • Cytokines
  • Growth factor
  • Neurocognitive impairment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Neurology
  • Immunology

Cite this

Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. / Suh, Hyeon Sook; Lo, Yungtai; Choi, Namjong; Letendre, Scott; Lee, Sunhee C.

In: Journal of Neuroinflammation, Vol. 12, No. 1, 72, 15.04.2015.

Research output: Contribution to journalArticle

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