Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals

Hyeon Sook Suh, Yungtai Lo, Namjong Choi, Scott Letendre, Sunhee C. Lee

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Clinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown. Methods: We measured the levels of IGF1, IGF2, IGFBP1, IGFBP2, and IGF2 receptor (IGF2R) in matching plasma and cerebrospinal fluid (CSF) samples of 107 HIV+ individuals from CNS HIV Antiretroviral Therapy Effects Research (CHARTER) and analyzed their associations with demographic and disease characteristics, as well as levels of several soluble inflammatory mediators (TNFα, IL-6, IL-10, IL-17, IP-10, MCP-1, and progranulin). We also determined whether IGF1 or IGF2 deficiency is associated with HIV-associated neurocognitive disorder (HAND) and whether the levels of soluble IGF2R (an IGF scavenging receptor, which we also have found to be a cofactor for HIV infection in vitro) correlate with HIV viral load (VL). Results: There was a positive correlation between the levels of IGF-binding proteins (IGFBPs) and those of inflammatory mediators: between plasma IGFBP1 and IL-17 (α coefficient 0.28, P=0.009), plasma IGFBP2 and IL-6 (α coefficient 0.209, P=0.021), CSF IGFBP1 and TNFα (α coefficient 0.394, P

Original languageEnglish (US)
Article number72
JournalJournal of Neuroinflammation
Volume12
Issue number1
DOIs
StatePublished - Apr 15 2015

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Keywords

  • Biomarker
  • Charter
  • Cytokines
  • Growth factor
  • Neurocognitive impairment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Neurology
  • Immunology

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