TY - JOUR
T1 - Insulin-like growth factors and leukocyte telomere length
T2 - The cardiovascular health study
AU - Kaplan, Robert C.
AU - Fitzpatrick, Annette L.
AU - Pollak, Michael N.
AU - Gardner, Jeffrey P.
AU - Jenny, Nancy S.
AU - McGinn, Aileen P.
AU - Kuller, Lewis H.
AU - Strickler, Howard D.
AU - Kimura, Masayuki
AU - Psaty, Bruce M.
AU - Aviv, Abraham
PY - 2009
Y1 - 2009
N2 - The insulin-like growth, factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of.08 kb in LTL for each standard deviation increase of IGF-1 (p =.04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.
AB - The insulin-like growth, factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of.08 kb in LTL for each standard deviation increase of IGF-1 (p =.04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.
KW - Epidemiology
KW - Factor
KW - Insulin-like growth
KW - Telomere length
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U2 - 10.1093/gerona/glp036
DO - 10.1093/gerona/glp036
M3 - Article
C2 - 19349587
AN - SCOPUS:70350458746
SN - 1079-5006
VL - 64
SP - 1103
EP - 1106
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 11
ER -
