Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults

Swapnil N. Rajpathak, Aileen P. McGinn, Howard D. Strickler, Thomas E. Rohan, Michael Pollak, Anne R. Cappola, Lewis Kuller, Xiao Nan Xue, Anne B. Newman, Elsa S. Strotmeyer, Bruce M. Psaty, Robert C. Kaplan

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50 Scopus citations

Abstract

Increasing evidence suggests that the insulin-like growth factor (IGF)-axis may play a role in glucose metabolism and may also be associated with systemic inflammation. The aim of this study was to evaluate the association of insulin-like growth factor-1 (IGF-I) and its binding proteins, IGFBP-1 and IGFBP-3, with glucose intolerance and inflammation among older adults. We conducted a cross-sectional analysis in a in a random subsample (n = 922) of the Cardiovascular Health Study (CHS), a prospective cohort of men and women ≥65 years. Mean IGFBP-1 levels were significantly lower in older adults with impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes compared to those with normal fasting and post-load glucose. High IGFBP-1 was associated with a reduced prevalence of IGT and IFG; the multivariable OR between extreme quartiles of IGFBP-1 was 0.60 (95% CI: 0.37, 0.95; p-trend: 0.03) for IGT and 0.41 (95% CI: 0.26, 0.64; p-trend: <0.01) for IFG. We did not find any significant association between IGF-I and glucose intolerance in this study and the association for IGFBP-3 was less clear. However, low levels of IGF-I and IGFBP-3 were associated with increased levels of markers of inflammation including C-reactive protein and interleukin-6 levels. We conclude that among adults ≥65 years, low IGFBP-1 levels are associated with increased prevalence of glucose intolerance. We did not confirm prior associations of low IGF-I with glucose intolerance in this cohort of older individuals.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalGrowth Hormone and IGF Research
Volume18
Issue number2
DOIs
StatePublished - Apr 1 2008

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Keywords

  • Glucose intolerance
  • IGF-I
  • IGFBP-I
  • Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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