Insulin-like growth factor-I restores microvascular autoregulation in experimental chronic renal failure

J. J. Lin, B. Tonshoff, N. Bouriquet, D. Casellas, F. J. Kaskel, L. C. Moore

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Impairment of autoregulation (AR) is associated with accelerated progression of chronic renal failure (CRF). As the bioavailability of insulin-like growth factor-I (IGF-I) is low in CRF, we investigated the effects of acute luminal application of 10 nm recombinant human IGF-I on AR in juxtamedullary (JM) afferent arterioles (AA) perfused in vitro with a blood solution [(~30% hematocrit (HCT)]. Studies were conducted in AA from adult male rats three to four weeks after five-sixths nephrectomy (Nx) by either surgical excision (N = 7) or infarction (N = 5) of two thirds of the remnant kidney, controls (N = 6) had sham surgery. AA from both Nx groups exhibited marked hypertrophy and impaired AR responses (60 to 140 mm Hg perfusion pressure), features more pronounced in the infarction group. Responses to abluminal acetylcholine (10 μM) were similar in sham and excision groups but were significantly blunted in the infarction group. All groups vasodilated significantly after Ca-channel blockade (10 mM MnCl2). IGF-I restored AR in AA from both Nx groups (P < 0.05, analysis of variance) while it vasodilated AA from controls. These results suggest that IGF-I may protect the glomerulus from injury by maintaining autoregulatory control of renal blood flow, thereby slowing the progression of CRF.

Original languageEnglish (US)
Pages (from-to)S195-S198
JournalKidney International, Supplement
Volume54
Issue number67
StatePublished - Jan 1 1998

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Keywords

  • Afferent arteriole
  • Autoregulation of blood pressure
  • Hemodynamics
  • Injury
  • Juxtamedullary
  • Progressive CRF
  • Rectomy

ASJC Scopus subject areas

  • Nephrology

Cite this

Lin, J. J., Tonshoff, B., Bouriquet, N., Casellas, D., Kaskel, F. J., & Moore, L. C. (1998). Insulin-like growth factor-I restores microvascular autoregulation in experimental chronic renal failure. Kidney International, Supplement, 54(67), S195-S198.