Insulin-like growth factor binding protein-4 as a marker of chronic lupus nephritis

Tianfu Wu, Chun Xie, Jie Han, Yujin Ye, Sandeep Singh, Jinchun Zhou, Yajuan Li, Huihua Ding, Quan Zhen Li, Xin Zhou, Chaim Putterman, Ramesh Saxena, Chandra Mohan

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Abstract

Kidney biopsy remains the mainstay of Lupus Nephritis (LN) diagnosis and prognostication. The objective of this study is to identify non-invasive biomarkers that closely parallel renal pathology in LN. Previous reports have demonstrated that serum Insulin-like growth factor binding protein 4 (IGFBP-4) was increased in diabetic nephropathy in both animal models and patients. We proceeded to assess if IGFBP4 could be associated with LN. We performed ELISA using the serum of 86 patients with LN. Normal healthy adults (N = 23) and patients with other glomerular diseases (N = 20) served as controls. Compared to the healthy controls or other glomerular disease controls, serum IGFBP-4 levels were significantly higher in the patients with LN. Serum IGFBP-4 did not correlate well with systemic lupus erythematosus disease activity index (SLEDAI), renal SLEDAI or proteinuria, but it did correlate with estimated glomerular filtration rate (R = 0.609, P <0.0001). Interestingly, in 18 patients with proliferative LN whose blood samples were obtained at the time of renal biopsy, serum IGFBP-4 levels correlated strongly with the chronicity index of renal pathology (R = 0.713, P <0.001). IGFBP-4 emerges a potential marker of lupus nephritis, reflective of renal pathology chronicity changes.

Original languageEnglish (US)
Article numbere0151491
JournalPLoS One
Volume11
Issue number3
DOIs
StatePublished - Mar 1 2016

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Wu, T., Xie, C., Han, J., Ye, Y., Singh, S., Zhou, J., Li, Y., Ding, H., Li, Q. Z., Zhou, X., Putterman, C., Saxena, R., & Mohan, C. (2016). Insulin-like growth factor binding protein-4 as a marker of chronic lupus nephritis. PLoS One, 11(3), [e0151491]. https://doi.org/10.1371/journal.pone.0151491