Insights to metabolic network evolution by fusion proteins.

Meena Kishore Sakharkar, Y. Yiting, Vincent T K Chow, Pandjassarame Kangueane

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Human fusion proteins consisting of two or more fusion partners of prokaryotic origin exhibit accreted function. Recent studies have elucidated the importance of fusion proteins in complex regulatory networks. The significance of fusion proteins in cellular networks and their evolutionary mechanism is largely unknown. Here, we discuss the association of six fusion proteins with the citric acid cycle. We define possible gene fusion scenarios and show that they produce metabolites with high connectivity for complex networking. Complex networking of metabolites requires proteins with incremental structural architectures and functional capabilities. Such higher order functionality is frequently provided by fusion proteins. Therefore, evolution of fusion proteins capable of producing metabolites with greater connectivity for enhanced cross-talk between pathways is critical for the selection of multiple trajectories in maintaining a stoichiometric balance during regulation. The association of six fusion proteins with the citric acid cycle and their capability to produce metabolites with high connectivity index is intriguing. This suggests that fusion gene products and their evolution have had a key role in the selection of complex multifaceted networks. In addition, we propose that fusion proteins have gained additive biochemical function for a balanced regulation of metabolic networks.

Original languageEnglish (US)
Pages (from-to)1070-1078
Number of pages9
JournalFrontiers in Bioscience
Volume10
StatePublished - 2005
Externally publishedYes

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Metabolic Networks and Pathways
Fusion reactions
Proteins
Metabolites
Citric Acid Cycle
Gene Fusion
Genes
Critical Pathways
Complex networks
Trajectories

Cite this

Sakharkar, M. K., Yiting, Y., Chow, V. T. K., & Kangueane, P. (2005). Insights to metabolic network evolution by fusion proteins. Frontiers in Bioscience, 10, 1070-1078.

Insights to metabolic network evolution by fusion proteins. / Sakharkar, Meena Kishore; Yiting, Y.; Chow, Vincent T K; Kangueane, Pandjassarame.

In: Frontiers in Bioscience, Vol. 10, 2005, p. 1070-1078.

Research output: Contribution to journalArticle

Sakharkar, MK, Yiting, Y, Chow, VTK & Kangueane, P 2005, 'Insights to metabolic network evolution by fusion proteins.', Frontiers in Bioscience, vol. 10, pp. 1070-1078.
Sakharkar MK, Yiting Y, Chow VTK, Kangueane P. Insights to metabolic network evolution by fusion proteins. Frontiers in Bioscience. 2005;10:1070-1078.
Sakharkar, Meena Kishore ; Yiting, Y. ; Chow, Vincent T K ; Kangueane, Pandjassarame. / Insights to metabolic network evolution by fusion proteins. In: Frontiers in Bioscience. 2005 ; Vol. 10. pp. 1070-1078.
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