Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction

Robert E. Michler, Jean L. Rouleau, Hussein R. Al-Khalidi, Robert O. Bonow, Patricia A. Pellikka, Gerald M. Pohost, Thomas A. Holly, Jae K. Oh, Francois Dagenais, Carmelo Milano, Krzysztof Wrobel, Jan Pirk, Imtiaz S. Ali, Robert H. Jones, Eric J. Velazquez, Kerry L. Lee, Marisa Di Donato

Research output: Contribution to journalArticle

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Abstract

Objective: The present analysis of the Surgical Treatment for Ischemic Heart Failure randomized trial data examined the left ventricular volumes at baseline and 4 months after surgery to determine whether any magnitude of postoperative reduction in end-systolic volume affected survival after coronary artery bypass grafting alone compared with bypass grafting plus surgical ventricular reconstruction. Methods: Of the 1000 patients randomized, 555 underwent an operation and had a paired imaging assessment with the same modality at baseline and 4 months postoperatively. Of the remaining 455 patients, 424 either died before the 4-month study or did not have paired imaging tests and were excluded, and 21 were not considered because they had died before surgery or did not receive surgery. Results: Surgical ventricular reconstruction resulted in improved survival compared with coronary artery bypass grafting alone when the postoperative end-systolic volume index was 70 mL/m2 or less. However, the opposite was true for patients achieving a postoperative volume index greater than 70 mL/m2. A reduction in the end-systolic volume index of 30% or more compared with baseline was an infrequent event in both treatment groups and did not produce a statistically significant survival benefit with ventricular reconstruction. Conclusions: In patients undergoing coronary artery bypass grafting plus surgical ventricular reconstruction, a survival benefit was realized compared with bypass alone, with the achievement of a postoperative end-systolic volume index of 70 mL/m 2 or less. Extensive ventricular remodeling at baseline might limit the ability of ventricular reconstruction to achieve a sufficient reduction in volume and clinical benefit.

Original languageEnglish (US)
JournalJournal of Thoracic and Cardiovascular Surgery
Volume146
Issue number5
DOIs
StatePublished - Nov 2013

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Coronary Artery Bypass
Survival
Ventricular Remodeling
Aptitude
Heart Failure
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Insights from the STICH trial : Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction. / Michler, Robert E.; Rouleau, Jean L.; Al-Khalidi, Hussein R.; Bonow, Robert O.; Pellikka, Patricia A.; Pohost, Gerald M.; Holly, Thomas A.; Oh, Jae K.; Dagenais, Francois; Milano, Carmelo; Wrobel, Krzysztof; Pirk, Jan; Ali, Imtiaz S.; Jones, Robert H.; Velazquez, Eric J.; Lee, Kerry L.; Di Donato, Marisa.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 146, No. 5, 11.2013.

Research output: Contribution to journalArticle

Michler, RE, Rouleau, JL, Al-Khalidi, HR, Bonow, RO, Pellikka, PA, Pohost, GM, Holly, TA, Oh, JK, Dagenais, F, Milano, C, Wrobel, K, Pirk, J, Ali, IS, Jones, RH, Velazquez, EJ, Lee, KL & Di Donato, M 2013, 'Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction', Journal of Thoracic and Cardiovascular Surgery, vol. 146, no. 5. https://doi.org/10.1016/j.jtcvs.2012.09.007
Michler, Robert E. ; Rouleau, Jean L. ; Al-Khalidi, Hussein R. ; Bonow, Robert O. ; Pellikka, Patricia A. ; Pohost, Gerald M. ; Holly, Thomas A. ; Oh, Jae K. ; Dagenais, Francois ; Milano, Carmelo ; Wrobel, Krzysztof ; Pirk, Jan ; Ali, Imtiaz S. ; Jones, Robert H. ; Velazquez, Eric J. ; Lee, Kerry L. ; Di Donato, Marisa. / Insights from the STICH trial : Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction. In: Journal of Thoracic and Cardiovascular Surgery. 2013 ; Vol. 146, No. 5.
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abstract = "Objective: The present analysis of the Surgical Treatment for Ischemic Heart Failure randomized trial data examined the left ventricular volumes at baseline and 4 months after surgery to determine whether any magnitude of postoperative reduction in end-systolic volume affected survival after coronary artery bypass grafting alone compared with bypass grafting plus surgical ventricular reconstruction. Methods: Of the 1000 patients randomized, 555 underwent an operation and had a paired imaging assessment with the same modality at baseline and 4 months postoperatively. Of the remaining 455 patients, 424 either died before the 4-month study or did not have paired imaging tests and were excluded, and 21 were not considered because they had died before surgery or did not receive surgery. Results: Surgical ventricular reconstruction resulted in improved survival compared with coronary artery bypass grafting alone when the postoperative end-systolic volume index was 70 mL/m2 or less. However, the opposite was true for patients achieving a postoperative volume index greater than 70 mL/m2. A reduction in the end-systolic volume index of 30{\%} or more compared with baseline was an infrequent event in both treatment groups and did not produce a statistically significant survival benefit with ventricular reconstruction. Conclusions: In patients undergoing coronary artery bypass grafting plus surgical ventricular reconstruction, a survival benefit was realized compared with bypass alone, with the achievement of a postoperative end-systolic volume index of 70 mL/m 2 or less. Extensive ventricular remodeling at baseline might limit the ability of ventricular reconstruction to achieve a sufficient reduction in volume and clinical benefit.",
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T2 - Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction

AU - Michler, Robert E.

AU - Rouleau, Jean L.

AU - Al-Khalidi, Hussein R.

AU - Bonow, Robert O.

AU - Pellikka, Patricia A.

AU - Pohost, Gerald M.

AU - Holly, Thomas A.

AU - Oh, Jae K.

AU - Dagenais, Francois

AU - Milano, Carmelo

AU - Wrobel, Krzysztof

AU - Pirk, Jan

AU - Ali, Imtiaz S.

AU - Jones, Robert H.

AU - Velazquez, Eric J.

AU - Lee, Kerry L.

AU - Di Donato, Marisa

PY - 2013/11

Y1 - 2013/11

N2 - Objective: The present analysis of the Surgical Treatment for Ischemic Heart Failure randomized trial data examined the left ventricular volumes at baseline and 4 months after surgery to determine whether any magnitude of postoperative reduction in end-systolic volume affected survival after coronary artery bypass grafting alone compared with bypass grafting plus surgical ventricular reconstruction. Methods: Of the 1000 patients randomized, 555 underwent an operation and had a paired imaging assessment with the same modality at baseline and 4 months postoperatively. Of the remaining 455 patients, 424 either died before the 4-month study or did not have paired imaging tests and were excluded, and 21 were not considered because they had died before surgery or did not receive surgery. Results: Surgical ventricular reconstruction resulted in improved survival compared with coronary artery bypass grafting alone when the postoperative end-systolic volume index was 70 mL/m2 or less. However, the opposite was true for patients achieving a postoperative volume index greater than 70 mL/m2. A reduction in the end-systolic volume index of 30% or more compared with baseline was an infrequent event in both treatment groups and did not produce a statistically significant survival benefit with ventricular reconstruction. Conclusions: In patients undergoing coronary artery bypass grafting plus surgical ventricular reconstruction, a survival benefit was realized compared with bypass alone, with the achievement of a postoperative end-systolic volume index of 70 mL/m 2 or less. Extensive ventricular remodeling at baseline might limit the ability of ventricular reconstruction to achieve a sufficient reduction in volume and clinical benefit.

AB - Objective: The present analysis of the Surgical Treatment for Ischemic Heart Failure randomized trial data examined the left ventricular volumes at baseline and 4 months after surgery to determine whether any magnitude of postoperative reduction in end-systolic volume affected survival after coronary artery bypass grafting alone compared with bypass grafting plus surgical ventricular reconstruction. Methods: Of the 1000 patients randomized, 555 underwent an operation and had a paired imaging assessment with the same modality at baseline and 4 months postoperatively. Of the remaining 455 patients, 424 either died before the 4-month study or did not have paired imaging tests and were excluded, and 21 were not considered because they had died before surgery or did not receive surgery. Results: Surgical ventricular reconstruction resulted in improved survival compared with coronary artery bypass grafting alone when the postoperative end-systolic volume index was 70 mL/m2 or less. However, the opposite was true for patients achieving a postoperative volume index greater than 70 mL/m2. A reduction in the end-systolic volume index of 30% or more compared with baseline was an infrequent event in both treatment groups and did not produce a statistically significant survival benefit with ventricular reconstruction. Conclusions: In patients undergoing coronary artery bypass grafting plus surgical ventricular reconstruction, a survival benefit was realized compared with bypass alone, with the achievement of a postoperative end-systolic volume index of 70 mL/m 2 or less. Extensive ventricular remodeling at baseline might limit the ability of ventricular reconstruction to achieve a sufficient reduction in volume and clinical benefit.

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