Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

Ebany J. Martinez-Finley; Daiana Silva Avila; Sudipta Chakraborty; Michael Aschner

doi:10.1039/c0mt00064g

Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

Ebany J. Martinez-Finley, Daiana Silva Avila, Sudipta Chakraborty, Michael Aschner

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.

Original language	English (US)
Pages (from-to)	271-279
Number of pages	9
Journal	Metallomics
Volume	3
Issue number	3
DOIs	https://doi.org/10.1039/c0mt00064g
State	Published - Mar 2011
Externally published	Yes

ASJC Scopus subject areas

Chemistry (miscellaneous)
Biophysics
Biomaterials
Biochemistry
Metals and Alloys

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AB - Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.

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Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

Abstract

ASJC Scopus subject areas

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