Abstract
Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 271-279 |
| Number of pages | 9 |
| Journal | Metallomics |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biomaterials
- Metals and Alloys
- Chemistry (miscellaneous)
- Biochemistry
- Biophysics
Cite this
Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases. / Martinez-Finley, Ebany J.; Avila, Daiana Silva; Chakraborty, Sudipta; Aschner, Michael.
In: Metallomics, Vol. 3, No. 3, 03.2011, p. 271-279.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases
AU - Martinez-Finley, Ebany J.
AU - Avila, Daiana Silva
AU - Chakraborty, Sudipta
AU - Aschner, Michael
PY - 2011/3
Y1 - 2011/3
N2 - Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
AB - Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
UR - http://www.scopus.com/inward/record.url?scp=79952502868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952502868&partnerID=8YFLogxK
U2 - 10.1039/c0mt00064g
DO - 10.1039/c0mt00064g
M3 - Article
C2 - 21210060
AN - SCOPUS:79952502868
VL - 3
SP - 271
EP - 279
JO - Metallomics
JF - Metallomics
SN - 1756-5901
IS - 3
ER -