Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

Ebany J. Martinez-Finley, Daiana Silva Avila, Sudipta Chakraborty, Michael Aschner

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.

Original languageEnglish (US)
Pages (from-to)271-279
Number of pages9
JournalMetallomics
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 1 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Biophysics
  • Biomaterials
  • Biochemistry
  • Metals and Alloys

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