Insertional polymorphisms of full-length endogenous retroviruses in humans

Geoffrey Turner, Madalina Barbulescu, Mei Su, Michael I. Jensen-Seaman, Kenneth K. Kidd, Jack Lenz

Research output: Contribution to journalArticle

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Abstract

Human endogenous retrovirus K (HERV-K) is distinctive among the retroviruses in the human genome in that many HERV-K proviruses were inserted into the human germline after the human and chimpanzee lineages evolutionarily diverged [1, 2]. However, all full-length endogenous retroviruses described to date in humans are sufficiently old that all humans examined were homozygous for their presence [1]. Moreover, none are intact; all have lethal mutations [1, 3, 4]. Here, we describe the first endogenous retroviruses in humans for which both the full-length provirus and the preintegration site alleles are shown to be present in the human population today. One provirus, called HERV-K113, was present in about 30% of tested individuals, while a second, called HERV-K115, was found in about 15%. HERV-K113 has full-length open reading frames (ORFs) for all viral proteins and lacks any nonsynomymous substitutions in amino acid motifs that are well conserved among retroviruses. This is the first such endogenous retrovirus identified in humans. These findings indicate that HERV-K remained capable of reinfecting humans through very recent evolutionary times and that HERV-K113 is an excellent candidate for an endogenous retrovirus that is capable of reinfecting humans today.

Original languageEnglish (US)
Pages (from-to)1531-1535
Number of pages5
JournalCurrent Biology
Volume11
Issue number19
DOIs
StatePublished - Oct 2 2001

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Retroviridae
Endogenous Retroviruses
Proviruses
Polymorphism
genetic polymorphism
Viral Proteins
proviruses
Substitution reactions
Genes
Amino Acids
amino acid motifs
Amino Acid Motifs
Pan troglodytes
Human Genome
viral proteins
Open Reading Frames
lethal genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Turner, G., Barbulescu, M., Su, M., Jensen-Seaman, M. I., Kidd, K. K., & Lenz, J. (2001). Insertional polymorphisms of full-length endogenous retroviruses in humans. Current Biology, 11(19), 1531-1535. https://doi.org/10.1016/S0960-9822(01)00455-9

Insertional polymorphisms of full-length endogenous retroviruses in humans. / Turner, Geoffrey; Barbulescu, Madalina; Su, Mei; Jensen-Seaman, Michael I.; Kidd, Kenneth K.; Lenz, Jack.

In: Current Biology, Vol. 11, No. 19, 02.10.2001, p. 1531-1535.

Research output: Contribution to journalArticle

Turner, G, Barbulescu, M, Su, M, Jensen-Seaman, MI, Kidd, KK & Lenz, J 2001, 'Insertional polymorphisms of full-length endogenous retroviruses in humans', Current Biology, vol. 11, no. 19, pp. 1531-1535. https://doi.org/10.1016/S0960-9822(01)00455-9
Turner, Geoffrey ; Barbulescu, Madalina ; Su, Mei ; Jensen-Seaman, Michael I. ; Kidd, Kenneth K. ; Lenz, Jack. / Insertional polymorphisms of full-length endogenous retroviruses in humans. In: Current Biology. 2001 ; Vol. 11, No. 19. pp. 1531-1535.
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