Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking

June Chunqiu Hou, Jeffrey E. Pessin

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Glucose transporter 4 (GLUT4) is the major insulin-regulated glucose transporter expressed mainly in muscle and adipose tissue. GLUT4 is stored in a poorly characterized intracellular vesicular compartment and translocates to the cell surface in response to insulin stimulation resulting in an increased glucose uptake. This process is essential for the maintenance of normal glucose homeostasis and involves a complex interplay of trafficking events and intracellular signaling cascades. Recent studies have identified sortilin as an essential element for the formation of GLUT4 storage vesicles during adipogenesis and Golgi-localized γ-ear-containing Arf-binding protein (GGA) as a key coat adaptor for the entry of newly synthesized GLUT4 into the specialized compartment. Insulin-stimulated GLUT4 translocation from this compartment to the plasma membrane appears to require the Akt/protein kinase B substrate termed AS160 (Akt substrate of 160 kDa). In addition, the VPS9 domain-containing protein Gapex-5 in complex with CIP4 appears to function as a Rab31 guanylnucleotide exchange factor that is necessary for insulin-stimulated GLUT4 translocation. Here, we attempt to summarize recent advances in GLUT4 vesicle biogenesis, intracellular trafficking and membrane fusion.

Original languageEnglish (US)
Pages (from-to)466-473
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume19
Issue number4
DOIs
StatePublished - Aug 2007
Externally publishedYes

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Facilitative Glucose Transport Proteins
Exocytosis
Endocytosis
Insulin
Glucose
Adipogenesis
Proto-Oncogene Proteins c-akt
Intracellular Membranes
Membrane Fusion
Ear
Adipose Tissue
Carrier Proteins
Homeostasis
Maintenance
Cell Membrane
Muscles

ASJC Scopus subject areas

  • Cell Biology

Cite this

Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking. / Hou, June Chunqiu; Pessin, Jeffrey E.

In: Current Opinion in Cell Biology, Vol. 19, No. 4, 08.2007, p. 466-473.

Research output: Contribution to journalArticle

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