Inject and infect

How Mycobacterium tuberculosis exploits its major virulence-associated type VII secretion system, ESX-1

Sangeeta Tiwari, Rosalyn Casey, Celia W. Goulding, Suzie Hingley-Wilson, William R. Jacobs

Research output: Contribution to journalArticle

Abstract

Mycobacterium tuberculosis is an ancient master of the art of causing human disease. One important weapon within its fully loaded arsenal is the type VII secretion system. M. tuberculosis has five of them: ESAT-6 secretion systems (ESX) 1 to 5. ESX-1 has long been recognized as a major cause of attenuation of the FDA-licensed vaccine Mycobacterium bovis BCG, but its importance in disease progression and transmission has recently been elucidated in more detail. This review summarizes the recent advances in (i) the understanding of the ESX-1 structure and components, (ii) our knowledge of ESX-1's role in hijacking macrophage function to set a path for infection and dissemination, and (iii) the development of interventions that utilize ESX-1 for diagnosis, drug interventions, host-directed therapies, and vaccines.

Original languageEnglish (US)
Article numberBAI-0024-2019
JournalMicrobiology Spectrum
Volume7
Issue number3
DOIs
StatePublished - May 1 2019

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tuberculosis
vaccine
Mycobacterium bovis
virulence
Mycobacterium tuberculosis
secretion
Virulence
Active Immunotherapy
Weapons
weapon
Art
art
Disease Progression
drug
Vaccines
Macrophages
Infection
Pharmaceutical Preparations
Type VII Secretion Systems
infection

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • Immunology and Microbiology(all)
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases

Cite this

Inject and infect : How Mycobacterium tuberculosis exploits its major virulence-associated type VII secretion system, ESX-1. / Tiwari, Sangeeta; Casey, Rosalyn; Goulding, Celia W.; Hingley-Wilson, Suzie; Jacobs, William R.

In: Microbiology Spectrum, Vol. 7, No. 3, BAI-0024-2019, 01.05.2019.

Research output: Contribution to journalArticle

Tiwari, Sangeeta ; Casey, Rosalyn ; Goulding, Celia W. ; Hingley-Wilson, Suzie ; Jacobs, William R. / Inject and infect : How Mycobacterium tuberculosis exploits its major virulence-associated type VII secretion system, ESX-1. In: Microbiology Spectrum. 2019 ; Vol. 7, No. 3.
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