Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Jianhua Ge, Yi Zhang, Zhirui Dong, Jianbo Jia, Jiannan Zhu, Xiaoyuan Miao, Bing Yan

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

Original languageEnglish (US)
Pages (from-to)20771-20778
Number of pages8
JournalACS Applied Materials and Interfaces
Volume9
Issue number24
DOIs
Publication statusPublished - Jun 21 2017
Externally publishedYes

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Keywords

  • drug delivery
  • magnetic implant
  • nanocarrier
  • nanomedicine
  • targeting

ASJC Scopus subject areas

  • Materials Science(all)

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