Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Jianhua Ge, Yi Zhang, Zhirui Dong, Jianbo Jia, Jiannan Zhu, Xiaoyuan Miao, Bing Yan

Research output: Contribution to journalArticle

Abstract

Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

Original languageEnglish (US)
Pages (from-to)20771-20778
Number of pages8
JournalACS Applied Materials and Interfaces
Volume9
Issue number24
DOIs
StatePublished - Jun 21 2017
Externally publishedYes

Fingerprint

Magnetics
Nanomedicine
Medical nanotechnology
Magnetism
Magnetic Fields
Drug Delivery Systems
Drug delivery
Biocompatibility
Scaffolds
Magnetic fields
Cells
Pharmaceutical Preparations
Neoplasms

Keywords

  • drug delivery
  • magnetic implant
  • nanocarrier
  • nanomedicine
  • targeting

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant. / Ge, Jianhua; Zhang, Yi; Dong, Zhirui; Jia, Jianbo; Zhu, Jiannan; Miao, Xiaoyuan; Yan, Bing.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 24, 21.06.2017, p. 20771-20778.

Research output: Contribution to journalArticle

Ge, Jianhua ; Zhang, Yi ; Dong, Zhirui ; Jia, Jianbo ; Zhu, Jiannan ; Miao, Xiaoyuan ; Yan, Bing. / Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant. In: ACS Applied Materials and Interfaces. 2017 ; Vol. 9, No. 24. pp. 20771-20778.
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