Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Jianhua Ge; Yi Zhang; Zhirui Dong; Jianbo Jia; Jiannan Zhu; Xiaoyuan Miao; Bing Yan

doi:10.1021/acsami.7b05009

Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Jianhua Ge, Yi Zhang, Zhirui Dong, Jianbo Jia, Jiannan Zhu, Xiaoyuan Miao, Bing Yan

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe₃O₄/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

Original language	English (US)
Pages (from-to)	20771-20778
Number of pages	8
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	24
DOIs	https://doi.org/10.1021/acsami.7b05009
State	Published - Jun 21 2017
Externally published	Yes

Keywords

drug delivery
magnetic implant
nanocarrier
nanomedicine
targeting

ASJC Scopus subject areas

Materials Science(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.7b05009

Cite this

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title = "Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant",

abstract = "Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.",

keywords = "drug delivery, magnetic implant, nanocarrier, nanomedicine, targeting",

author = "Jianhua Ge and Yi Zhang and Zhirui Dong and Jianbo Jia and Jiannan Zhu and Xiaoyuan Miao and Bing Yan",

note = "Funding Information: This work was supported by the National Key Research and Development Program of China (2016YFA0203103) the National Natural Science Foundation of China (91543204 and 91643204) and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB14030401). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acsami.7b05009",

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AU - Ge, Jianhua

AU - Zhang, Yi

AU - Dong, Zhirui

AU - Jia, Jianbo

AU - Zhu, Jiannan

AU - Miao, Xiaoyuan

AU - Yan, Bing

N1 - Funding Information: This work was supported by the National Key Research and Development Program of China (2016YFA0203103) the National Natural Science Foundation of China (91543204 and 91643204) and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB14030401). Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/6/21

Y1 - 2017/6/21

N2 - Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

AB - Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

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KW - magnetic implant

KW - nanocarrier

KW - nanomedicine

KW - targeting

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Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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