Initial testing (Stage 1) of TAK-701, a humanized hepatocyte growth factor binding antibody, by the pediatric preclinical testing program

Peter J. Houghton; Raushan T. Kurmasheva; E. Anders Kolb; Jianrong Wu; Richard Gorlick; John M. Maris; Malcolm A. Smith

doi:10.1002/pbc.24756

Initial testing (Stage 1) of TAK-701, a humanized hepatocyte growth factor binding antibody, by the pediatric preclinical testing program

Peter J. Houghton, Raushan T. Kurmasheva, E. Anders Kolb, Jianrong Wu, Richard Gorlick, John M. Maris, Malcolm A. Smith

Pediatrics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

TAK-701 is a humanized antibody that binds hepatocyte growth factor (HGF), thus suppressing c-Met transduced signaling and c-Met dependent proliferation and migration of tumor cells. Six childhood solid tumor xenografts were selected for evaluating TAK-701 based on immunochemical detection of HGF/c-Met autocrine signaling [i.e., pMet(Tyr1349) and HGF positive]. TAK-701 was tested using a dose of 30mg/kg administered by the intraperitoneal (IP) route twice weekly for 4 weeks. TAK-701 did not induce significant differences in EFS distribution in treated tumors compared to control tumors. Objective responses were not observed in any of the tested solid tumor xenografts.

Original language	English (US)
Pages (from-to)	380-382
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	2
DOIs	https://doi.org/10.1002/pbc.24756
State	Published - Feb 2014

Keywords

C-Met inhibition
Developmental therapeutics
Preclinical testing

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.24756

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title = "Initial testing (Stage 1) of TAK-701, a humanized hepatocyte growth factor binding antibody, by the pediatric preclinical testing program",

abstract = "TAK-701 is a humanized antibody that binds hepatocyte growth factor (HGF), thus suppressing c-Met transduced signaling and c-Met dependent proliferation and migration of tumor cells. Six childhood solid tumor xenografts were selected for evaluating TAK-701 based on immunochemical detection of HGF/c-Met autocrine signaling [i.e., pMet(Tyr1349) and HGF positive]. TAK-701 was tested using a dose of 30mg/kg administered by the intraperitoneal (IP) route twice weekly for 4 weeks. TAK-701 did not induce significant differences in EFS distribution in treated tumors compared to control tumors. Objective responses were not observed in any of the tested solid tumor xenografts.",

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AU - Houghton, Peter J.

AU - Kurmasheva, Raushan T.

AU - Kolb, E. Anders

AU - Wu, Jianrong

AU - Gorlick, Richard

AU - Maris, John M.

AU - Smith, Malcolm A.

PY - 2014/2

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AB - TAK-701 is a humanized antibody that binds hepatocyte growth factor (HGF), thus suppressing c-Met transduced signaling and c-Met dependent proliferation and migration of tumor cells. Six childhood solid tumor xenografts were selected for evaluating TAK-701 based on immunochemical detection of HGF/c-Met autocrine signaling [i.e., pMet(Tyr1349) and HGF positive]. TAK-701 was tested using a dose of 30mg/kg administered by the intraperitoneal (IP) route twice weekly for 4 weeks. TAK-701 did not induce significant differences in EFS distribution in treated tumors compared to control tumors. Objective responses were not observed in any of the tested solid tumor xenografts.

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Initial testing (Stage 1) of TAK-701, a humanized hepatocyte growth factor binding antibody, by the pediatric preclinical testing program

Abstract

Keywords

ASJC Scopus subject areas

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