Initial testing of Aplidin by the pediatric pre-clinical testing program

Christopher L. Morton; Peter J. Houghton; Richard Gorlick; E. Anders Kolb; Richard Lock; Hernan Carol; Stephen T. Keir; C. Patrick Reynolds; Min H. Kang; John M. Maris; Catherine Billups; Malcolm A. Smith

doi:10.1002/pbc.21976

Initial testing of Aplidin by the pediatric pre-clinical testing program

Christopher L. Morton, Peter J. Houghton, Richard Gorlick, E. Anders Kolb, Richard Lock, Hernan Carol, Stephen T. Keir, C. Patrick Reynolds, Min H. Kang, John M. Maris, Catherine Billups, Malcolm A. Smith

Pediatrics

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Aplidin was tested in vitro at concentrations ranging from from 0.1 nM to 1.0 μM and in vivo at a dose of 0.6 mg/kg administered intraperitoneally on an every 4 days x 3-schedule that was repeated at day 21. In vitro, Aplidin was most active against acute lymphoblastic leukemia (ALL) cell lines. In vivo, Aplidin induced significant differences in EFS distribution in 12 of 28 (43%) solid tumor models and 2 of 6 evaluable ALL models. Aplidin showed potent in vitro activity and induced significant in vivo tumor growth inhibition in some xenografts, but did not induce tumor regressions.

Original language	English (US)
Pages (from-to)	509-512
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	53
Issue number	3
DOIs	https://doi.org/10.1002/pbc.21976
State	Published - Sep 2009

Keywords

Aplidin
Developmental therapeutics
Pre-clinical testing

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.21976

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Morton, C. L., Houghton, P. J., Gorlick, R., Kolb, E. A., Lock, R., Carol, H., Keir, S. T., Reynolds, C. P., Kang, M. H., Maris, J. M., Billups, C., & Smith, M. A. (2009). Initial testing of Aplidin by the pediatric pre-clinical testing program. Pediatric Blood and Cancer, 53(3), 509-512. https://doi.org/10.1002/pbc.21976

Initial testing of Aplidin by the pediatric pre-clinical testing program. / Morton, Christopher L.; Houghton, Peter J.; Gorlick, Richard; Kolb, E. Anders; Lock, Richard; Carol, Hernan; Keir, Stephen T.; Reynolds, C. Patrick; Kang, Min H.; Maris, John M.; Billups, Catherine; Smith, Malcolm A.

In: Pediatric Blood and Cancer, Vol. 53, No. 3, 09.2009, p. 509-512.

Research output: Contribution to journal › Article

Morton, Christopher L. ; Houghton, Peter J. ; Gorlick, Richard ; Kolb, E. Anders ; Lock, Richard ; Carol, Hernan ; Keir, Stephen T. ; Reynolds, C. Patrick ; Kang, Min H. ; Maris, John M. ; Billups, Catherine ; Smith, Malcolm A. / Initial testing of Aplidin by the pediatric pre-clinical testing program. In: Pediatric Blood and Cancer. 2009 ; Vol. 53, No. 3. pp. 509-512.

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