Inhibition of transcriptipnal regulator Yin-Yang-1 by association with c-Myc

A. Shrivastava, S. Saleque, Ganjam V. Kalpana, S. Artandi, S. P. Goff, K. Calame

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDN A) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

Original languageEnglish (US)
Pages (from-to)1889-1892
Number of pages4
JournalScience
Volume262
Issue number5141
StatePublished - Dec 17 1993
Externally publishedYes

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Yin-Yang
Complementary DNA
Activator Appliances
Two-Hybrid System Techniques
Gene Library
Affinity Chromatography
Oncogenes
Genes

ASJC Scopus subject areas

  • General

Cite this

Shrivastava, A., Saleque, S., Kalpana, G. V., Artandi, S., Goff, S. P., & Calame, K. (1993). Inhibition of transcriptipnal regulator Yin-Yang-1 by association with c-Myc. Science, 262(5141), 1889-1892.

Inhibition of transcriptipnal regulator Yin-Yang-1 by association with c-Myc. / Shrivastava, A.; Saleque, S.; Kalpana, Ganjam V.; Artandi, S.; Goff, S. P.; Calame, K.

In: Science, Vol. 262, No. 5141, 17.12.1993, p. 1889-1892.

Research output: Contribution to journalArticle

Shrivastava, A, Saleque, S, Kalpana, GV, Artandi, S, Goff, SP & Calame, K 1993, 'Inhibition of transcriptipnal regulator Yin-Yang-1 by association with c-Myc', Science, vol. 262, no. 5141, pp. 1889-1892.
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K. Inhibition of transcriptipnal regulator Yin-Yang-1 by association with c-Myc. Science. 1993 Dec 17;262(5141):1889-1892.
Shrivastava, A. ; Saleque, S. ; Kalpana, Ganjam V. ; Artandi, S. ; Goff, S. P. ; Calame, K. / Inhibition of transcriptipnal regulator Yin-Yang-1 by association with c-Myc. In: Science. 1993 ; Vol. 262, No. 5141. pp. 1889-1892.
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