Inhibition of transcriptional regulator Yin-Yang-1 by association with c-myc

A. Shrivastava, S. Saleque, G. V. Kalpana, S. Artandi, S. P. Goff, K. Calame

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Abstract

Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

Original languageEnglish (US)
Pages (from-to)1889-1892
Number of pages4
JournalScience
Volume262
Issue number5141
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

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Shrivastava, A., Saleque, S., Kalpana, G. V., Artandi, S., Goff, S. P., & Calame, K. (1993). Inhibition of transcriptional regulator Yin-Yang-1 by association with c-myc. Science, 262(5141), 1889-1892. https://doi.org/10.1126/science.8266081