Inhibition of reverse transcriptase activity increases stability of the HIV-1 core

Yang Yang, Thomas Fricke, Felipe Diaz-Griffero

Research output: Contribution to journalArticle

52 Scopus citations


Previous studies showed that HIV-1 reverse transcription occurs during or before uncoating, linking mechanistically reverse transcription with uncoating. Here we show that inhibition of reverse transcriptase (RT) during HIV-1 infection by pharmacologic or genetic means increased the stability of the HIV-1 core during infection. Interestingly, HIV-1 particles with increased core stability were resistant to the core-destabilizing effects of rhesus TRIM5α (TRIM5αrh). Collectively, this work implies that the surface of the HIV-1 core is dynamic and changes upon the ongoing processes within the core.

Original languageEnglish (US)
Pages (from-to)683-687
Number of pages5
JournalJournal of virology
Issue number1
StatePublished - Jan 1 2013


ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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