Inhibition of quorum sensing in Vibrio harveyi by boronic acids

Nanting Ni; Gaurav Choudhary; Hanjing Peng; Minyong Li; Han Ting Chou; Chung Dar Lu; Eric S. Gilbert; Binghe Wang

doi:10.1111/j.1747-0285.2009.00834.x

Inhibition of quorum sensing in Vibrio harveyi by boronic acids

Nanting Ni, Gaurav Choudhary, Hanjing Peng, Minyong Li, Han Ting Chou, Chung Dar Lu, Eric S. Gilbert, Binghe Wang

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chemicals called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. In this paper, we describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC₅₀ values in the low to sub-micromolar range in whole cell assays.

Original language	English (US)
Pages (from-to)	51-56
Number of pages	6
Journal	Chemical Biology and Drug Design
Volume	74
Issue number	1
DOIs	https://doi.org/10.1111/j.1747-0285.2009.00834.x
State	Published - Jul 2009
Externally published	Yes

Keywords

Autoinducer-1
Autoinducer-2
Inhibitors
Luminescence

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Organic Chemistry

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10.1111/j.1747-0285.2009.00834.x

Cite this

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abstract = "Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chemicals called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. In this paper, we describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC50 values in the low to sub-micromolar range in whole cell assays.",

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AU - Chou, Han Ting

AU - Lu, Chung Dar

AU - Gilbert, Eric S.

AU - Wang, Binghe

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Inhibition of quorum sensing in Vibrio harveyi by boronic acids

Abstract

Keywords

ASJC Scopus subject areas

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