@article{a43545cbf73c4c05bb2405c734f4c180,
title = "Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration",
abstract = "Boutry et al. show that inhibition of lysosome membrane recycling leads to lysosomal accumulation of some glycosphingolipids (simple gangliosides), which contributes to neuronal death.",
keywords = "autophagic lysosome recovery, autophagy, glycosphingolipids, induced pluripotent stem cells, knockout, lipid metabolism, lysosomes, membrane trafficking, neurodegenerative disease, organoids",
author = "Maxime Boutry and Julien Branchu and C{\'e}line Lustremant and Claire Pujol and Julie Pernelle and Rapha{\"e}l Matusiak and Alexandre Seyer and Marion Poirel and Emeline Chu-Van and Alexandre Pierga and Kostantin Dobrenis and Puech, {Jean Philippe} and Catherine Caillaud and Alexandra Durr and Alexis Brice and Benoit Colsch and Fanny Mochel and {El Hachimi}, {Khalid Hamid} and Giovanni Stevanin and Fr{\'e}d{\'e}ric Darios",
note = "Funding Information: We thank Phenoparc, Histomics, IGenSeq, Celis, Celis-IPS, and ICM.quant facilities of the Institut du Cerveau et de la Moelle {\'E}pini{\`e}re for their contributions. This work was supported by “Investissements d{\textquoteright}Avenir” Program grants ANR-10-IAIHU-06 and ANR-11-INBS-0011 and received funding from the Verum Foundation (to A.B. and G.S.), the French Agency for Research ( ANR ) ( 13-ISV1-00002 to G.S. and MetaboHUB: ANR-11-INBS-0010 ), the GIS-Maladies Rares Foundation ( 06/GIS/PB/SJ/no.71 to G.S.), the Fondation Roger de Spoelberch (to A.B.), the European Union with the ANR (to A.B., Seventh Framework Programme–FP7, Omics Call [grant No. 305121 ]; to G.S., the E-Rare Programme Neurolipid [ ANR-13-ERARE-0003-02 ]), and the European Research Council ( European Research Council Starting Grant No. 311149 to F.D.). M.B. received a fellowship from the French Ministry of Research (Doctoral School ED3C). A.P. received an ARDoC fellowship ( 17012953 ) from the R{\'e}gion Ile de France (Doctoral School ED3C). Funding Information: We thank Phenoparc, Histomics, IGenSeq, Celis, Celis-IPS, and ICM.quant facilities of the Institut du Cerveau et de la Moelle {\'E}pini{\`e}re for their contributions. This work was supported by “Investissements d'Avenir” Program grants ANR-10-IAIHU-06 and ANR-11-INBS-0011 and received funding from the Verum Foundation (to A.B. and G.S.), the French Agency for Research (ANR) (13-ISV1-00002 to G.S. and MetaboHUB: ANR-11-INBS-0010), the GIS-Maladies Rares Foundation (06/GIS/PB/SJ/no.71 to G.S.), the Fondation Roger de Spoelberch (to A.B.), the European Union with the ANR (to A.B., Seventh Framework Programme–FP7, Omics Call [grant No. 305121]; to G.S., the E-Rare Programme Neurolipid [ANR-13-ERARE-0003-02]), and the European Research Council (European Research Council Starting Grant No. 311149 to F.D.). M.B. received a fellowship from the French Ministry of Research (Doctoral School ED3C). A.P. received an ARDoC fellowship (17012953) from the R{\'e}gion Ile de France (Doctoral School ED3C). Funding Information: We thank Phenoparc, Histomics, IGenSeq, Celis, Celis-IPS, and ICM.quant facilities of the Institut du Cerveau et de la Moelle ?pini?re for their contributions. This work was supported by ?Investissements d'Avenir? Program grants ANR-10-IAIHU-06 and ANR-11-INBS-0011 and received funding from the Verum Foundation (to A.B. and G.S.), the French Agency for Research (ANR) (13-ISV1-00002 to G.S. and MetaboHUB: ANR-11-INBS-0010), the GIS-Maladies Rares Foundation (06/GIS/PB/SJ/no.71 to G.S.), the Fondation Roger de Spoelberch (to A.B.), the European Union with the ANR (to A.B., Seventh Framework Programme?FP7, Omics Call [grant No. 305121]; to G.S., the E-Rare Programme Neurolipid [ANR-13-ERARE-0003-02]), and the European Research Council (European Research Council Starting Grant No. 311149 to F.D.). M.B. received a fellowship from the French Ministry of Research (Doctoral School ED3C). A.P. received an ARDoC fellowship (17012953) from the R?gion Ile de France (Doctoral School ED3C).",
year = "2018",
month = jun,
day = "26",
doi = "10.1016/j.celrep.2018.05.098",
language = "English (US)",
volume = "23",
pages = "3813--3826",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",
}