Boutry et al. show that inhibition of lysosome membrane recycling leads to lysosomal accumulation of some glycosphingolipids (simple gangliosides), which contributes to neuronal death.
- autophagic lysosome recovery
- induced pluripotent stem cells
- lipid metabolism
- membrane trafficking
- neurodegenerative disease
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)