Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Dec 1967|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)