Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D

Norman Fleischer; Harold Battarbee

doi:10.3181/00379727-126-32606

Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D

Norman Fleischer, Harold Battarbee

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.

Original language	English (US)
Pages (from-to)	922-925
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	126
Issue number	3
DOIs	https://doi.org/10.3181/00379727-126-32606
State	Published - Dec 1967
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D",

abstract = "Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.",

author = "Norman Fleischer and Harold Battarbee",

note = "Funding Information: The investigation was supported by Public Health Service Grant AM-05063 from the National Institute of Arthritis and Metabolic Diseases and Public Health Service Grants FR-00134, HE 05435 and FR-00259. 12 1967 126 3 922 925 ",

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AU - Battarbee, Harold

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N2 - Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.

AB - Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.

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Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D

Abstract

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