Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D

Norman Fleischer, Harold Battarbee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.

Original languageEnglish (US)
Pages (from-to)922-925
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume126
Issue number3
DOIs
StatePublished - 1967
Externally publishedYes

Fingerprint

Dactinomycin
Adrenocorticotropic Hormone
Dexamethasone
Rats
RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D. / Fleischer, Norman; Battarbee, Harold.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 126, No. 3, 1967, p. 922-925.

Research output: Contribution to journalArticle

@article{efba45d10c2c45ceb919dc839e32316b,
title = "Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D",
abstract = "Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.",
author = "Norman Fleischer and Harold Battarbee",
year = "1967",
doi = "10.3181/00379727-126-32606",
language = "English (US)",
volume = "126",
pages = "922--925",
journal = "Experimental Biology and Medicine",
issn = "1535-3702",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D

AU - Fleischer, Norman

AU - Battarbee, Harold

PY - 1967

Y1 - 1967

N2 - Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.

AB - Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.

UR - http://www.scopus.com/inward/record.url?scp=84976926894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976926894&partnerID=8YFLogxK

U2 - 10.3181/00379727-126-32606

DO - 10.3181/00379727-126-32606

M3 - Article

VL - 126

SP - 922

EP - 925

JO - Experimental Biology and Medicine

T2 - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 1535-3702

IS - 3

ER -