Inhibition of Dexamethasone Suppression of ACTH Secretion in vivo By Actinomycin D

Norman Fleischer, Harold Battarbee

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Actinomycin D inhibited the capacity of dexamethasone to suppress pituitary ACTH secretion in vivo in normal and adrenalectomized rats. While a definitive explanation for such results awaits further elucidation, the results are consistent with the hypothesis that dexamethasone inhibits ACTH secretion by a mechanism that involves RNA synthesis.

Original languageEnglish (US)
Pages (from-to)922-925
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume126
Issue number3
DOIs
Publication statusPublished - 1967
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this