Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani

Joseph L. Amprey; Gerald F. Späth; Steven A. Porcelli

doi:10.1128/IAI.72.1.589-592.2004

Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani

Joseph L. Amprey, Gerald F. Späth, Steven A. Porcelli

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

Original language	English (US)
Pages (from-to)	589-592
Number of pages	4
Journal	Infection and immunity
Volume	72
Issue number	1
DOIs	https://doi.org/10.1128/IAI.72.1.589-592.2004
State	Published - Jan 2004
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/IAI.72.1.589-592.2004

Cite this

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abstract = "Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.",

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AB - Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

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Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani

Abstract

ASJC Scopus subject areas

UN SDGs

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