Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani

Joseph L. Amprey, Gerald F. Späth, Steven A. Porcelli

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalInfection and Immunity
Volume72
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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