Inherited deficiency of the sixth component of complement: a silent or null gene

D. Glass, D. Raum, D. Balavitch, E. Kagan, A. Rabson, P. H. Schur, C. A. Alper

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Abstract

Four families have been studied, some members of which have inherited deficiency of the sixth component of complement. The genetically determined electrophoretic variants of C6 were evaluated in all family members. Seven individuals were found who did not have the variant found in the serum of the parent from whom they inherited the deficiency. It is inferred that the isolated low levels of C6 in these individuals results from the heterozygous state of a normal C6 variant gene and a silent or null C6 gene; the genes determining electrophoretic variants and the low serum levels of C6 are allelic.

Original languageEnglish (US)
Pages (from-to)538-541
Number of pages4
JournalJournal of Immunology
Volume120
Issue number2
Publication statusPublished - Dec 1 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Glass, D., Raum, D., Balavitch, D., Kagan, E., Rabson, A., Schur, P. H., & Alper, C. A. (1978). Inherited deficiency of the sixth component of complement: a silent or null gene. Journal of Immunology, 120(2), 538-541.