Inhaled prostacyclin and high-frequency oscillatory ventilation in a premature infant with respiratory syncytial virus-associated respiratory failure

Manoj Gupta, Stephen Guertin, Steve Martin, Said Omar

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In a 29-day-old premature infant with respiratory syncytial virus (RSV) pneumonia, we have shown an additive effect of high-frequency oscillatory ventilation (HFOV) and continuous inhalation of prostacyclin (iPGI2) with improvement of ventilation and oxygenation. The addition of continuous inhaled iPGI2 to HFOV was beneficial in the treatment of hypoxemic respiratory failure owing to RSV-associated pneumonia. The improvement in alveolar recruitment by increasing lung expansion by HFOV along with less ventilation-perfusion mismatch by iPGI2 appears to be responsible for the synergistic effect and favorable clinical outcome. We conclude that the combined therapy of HFOV and continuous inhaled iPGI2 may be considered in RSV-associated hypoxemic respiratory failure in pediatric patients.

Original languageEnglish (US)
Pages (from-to)e442-e445
JournalPediatrics
Volume130
Issue number2
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Keywords

  • Premature infant
  • Prostacyclin inhalation
  • Respiratory failure
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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