Influence of vitamin A on cervical dysplasia and carcinoma in situ

Judith Wylie-Rosett, S. L. Romney, N. S. Slagle

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A case-control study was undertaken to determine the dietary intake of vitamin A in women having abnormal uterocervical cytology. The study groups (87 cases and 82 controls) were drawn from a population of women who received a screening Pap test in the ambulatory health care section of a large municipal hospital center. A subset of cases (with abnormal cytology) were matched to controls for age, ethnicity, socioeconomic status, and parity. Nutrient intake and retinol binding protein concentrations were determinde; epidemiological data were also obtained. It was found that the subset of cases with severe dysplasia or carcinoma in situ (CIS) were more likely to have a total dietary vitamin A intake below the pooled median (3,450 IU) and/or a β-carotene intake below the pooled median (2,072 IU) than were normal controls (p<0.05 and p<0.025, respectively). Odds ratios revealed approximately a 3-fold greater risk for severe dysplasia or CIS in women with lowered vitamin A or β-carotene intake. In addition, retinol binding protein was either absent or undetectable in 78.8% of the dysplastic tissue samples, versus 23.5% of the normal tissue samples (p<0.005).

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalNutrition and Cancer
Volume6
Issue number1
StatePublished - 1984

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Uterine Cervical Dysplasia
Carcinoma in Situ
Vitamin A
carcinoma
vitamin A
Retinol-Binding Proteins
retinol-binding protein
Carotenoids
carotenes
cell biology
Cell Biology
Municipal Hospitals
Papanicolaou Test
socioeconomic status
Ambulatory Care
nationalities and ethnic groups
Parity
case-control studies
nutrient intake
Social Class

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Oncology

Cite this

Influence of vitamin A on cervical dysplasia and carcinoma in situ. / Wylie-Rosett, Judith; Romney, S. L.; Slagle, N. S.

In: Nutrition and Cancer, Vol. 6, No. 1, 1984, p. 49-57.

Research output: Contribution to journalArticle

Wylie-Rosett, Judith ; Romney, S. L. ; Slagle, N. S. / Influence of vitamin A on cervical dysplasia and carcinoma in situ. In: Nutrition and Cancer. 1984 ; Vol. 6, No. 1. pp. 49-57.
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