TY - JOUR
T1 - Influence of loop electrosurgical excision procedure on subsequent acquisition of new human papillomavirus infections
AU - Castle, Philip E.
AU - Kreimer, Aimée R.
AU - Wacholder, Sholom
AU - Wheeler, Cosette M.
AU - Koutsky, Laura A.
AU - Rydzak, Greg
AU - Buckman, Dennis W.
AU - Graubard, Barry
AU - Schiffman, Mark
N1 - Funding Information:
Financial support: The ASCUS-LSIL Triage Study was supported by the National Cancer Institute, National Institutes of Health (contracts CN-55153, CN-55154, CN-55155, CN-55156, CN-55157, CN-55158, CN-55159, and CN-55105). Some equipment and supplies used in these studies were donated or provided at reduced cost by Digene, Cytyc, National Testing Laboratories, DenVu, TriPath Imaging, and Roche Molecular Systems.
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Background. The impact of loop electrosurgical excision procedure (LEEP) treatment for cervical precancerous lesions on subsequent acquisition of new human papillomavirus (HPV) infections is not well described. Methods. The acquisition of new HPV infections was compared in HPV-positive women who underwent colposcopy and were treated by LEEP (n = 195) and those who were untreated (n = 1625) at entry into a 2-year study. Cumulative incidence rate ratios (IRRs) for treated versus untreated women at 6- and 24-months of follow-up, with 95% confidence intervals (CIs), were calculated for infection by individual HPV genotypes, any HPV genotypes, any carcinogenic HPV genotypes, any noncarcinogenic HPV genotypes, and phylogenetic groups of HPV genotypes. Results. Treated women were 29% less likely than untreated women to have carcinogenic HPV genotypes detected at 6-month follow-up visits (IRR, 0.71; 95% CI, 0.50-1.00) and were 18% less likely to have these genotypes detected at 24-month follow-up visits (IRR, 0.82; 95% CI, 0.68-1.01). Treated women were 56% less likely to have HPV genotypes of the α9 phylogenetic species (which includes HPV-16) detected at 6-month follow-up visits (IRR, 0.44; 95% CI, 0.23- 0.85) and were 40% less likely to have these genotype detected at 24-month follow-up visits (IRR, 0.60; 95% CI, 0.42-0.85). Conclusion. LEEP may reduce the acquisition of certain carcinogenic HPV genotypes related to HPV-16.
AB - Background. The impact of loop electrosurgical excision procedure (LEEP) treatment for cervical precancerous lesions on subsequent acquisition of new human papillomavirus (HPV) infections is not well described. Methods. The acquisition of new HPV infections was compared in HPV-positive women who underwent colposcopy and were treated by LEEP (n = 195) and those who were untreated (n = 1625) at entry into a 2-year study. Cumulative incidence rate ratios (IRRs) for treated versus untreated women at 6- and 24-months of follow-up, with 95% confidence intervals (CIs), were calculated for infection by individual HPV genotypes, any HPV genotypes, any carcinogenic HPV genotypes, any noncarcinogenic HPV genotypes, and phylogenetic groups of HPV genotypes. Results. Treated women were 29% less likely than untreated women to have carcinogenic HPV genotypes detected at 6-month follow-up visits (IRR, 0.71; 95% CI, 0.50-1.00) and were 18% less likely to have these genotypes detected at 24-month follow-up visits (IRR, 0.82; 95% CI, 0.68-1.01). Treated women were 56% less likely to have HPV genotypes of the α9 phylogenetic species (which includes HPV-16) detected at 6-month follow-up visits (IRR, 0.44; 95% CI, 0.23- 0.85) and were 40% less likely to have these genotype detected at 24-month follow-up visits (IRR, 0.60; 95% CI, 0.42-0.85). Conclusion. LEEP may reduce the acquisition of certain carcinogenic HPV genotypes related to HPV-16.
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U2 - 10.1086/598981
DO - 10.1086/598981
M3 - Article
C2 - 19405865
AN - SCOPUS:67650656228
SN - 0022-1899
VL - 199
SP - 1612
EP - 1620
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -