Influence of caffeine on force development and force-frequency relations in cat and rat heart muscle

A. H. Henderson, D. L. Brutsaert, Robert Forman, E. H. Sonnenblick

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

AUTHORS' SYNOPSIS: The effects of caffeine on isometric force development and force-frequency relationships were compared in cat and rat papillary muscle preparations. The frequency of contraction determined whether caffeine augmented or diminished contractile force in cat muscles, but caffeine depressed contractions under all conditions in rat muscles. The time course of contraction and relaxation was slowed in both species by 10 mM caffeine but slightly abbreviated by 1 mM caffeine in the rat. The onset of the effects of caffeine was equally rapid in both species. Caffeine abolished post extrasystolic potentiation in both species and caused paradoxical post extrasystolic depression in rat muscles.

Original languageEnglish (US)
Pages (from-to)162-172
Number of pages11
JournalCardiovascular Research
Volume8
Issue number2
DOIs
StatePublished - Mar 1974
Externally publishedYes

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Rat Heart
Caffeine
Muscle
Rats
Myocardium
Cats
Contraction
Muscles
Isometric
Preparation
Papillary Muscles
Influence
Rat
Mm

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Influence of caffeine on force development and force-frequency relations in cat and rat heart muscle. / Henderson, A. H.; Brutsaert, D. L.; Forman, Robert; Sonnenblick, E. H.

In: Cardiovascular Research, Vol. 8, No. 2, 03.1974, p. 162-172.

Research output: Contribution to journalArticle

Henderson, A. H. ; Brutsaert, D. L. ; Forman, Robert ; Sonnenblick, E. H. / Influence of caffeine on force development and force-frequency relations in cat and rat heart muscle. In: Cardiovascular Research. 1974 ; Vol. 8, No. 2. pp. 162-172.
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