Infliximab reduces myeloperoxidase concentration in chronic inflammatory joint diseases

Montserrat Feijóo; Isaac Túnez; Inmaculada Tasset; Pedro Montilla; Verónica Pérez-Guijo; Elisa Muñoz-Gomariz; Adela Ruiz; Ruxandra Schiotis; Eduardo Collantes

doi:10.1159/000200022

Infliximab reduces myeloperoxidase concentration in chronic inflammatory joint diseases

Montserrat Feijóo, Isaac Túnez, Inmaculada Tasset, Pedro Montilla, Verónica Pérez-Guijo, Elisa Muñoz-Gomariz, Adela Ruiz, Ruxandra Schiotis, Eduardo Collantes

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The present study evaluated the effect of infliximab on the myeloperoxidase (MPO) concentration in chronic inflammatory joint disease. Eighteen patients were divided into active and inactive groups. Erythrocyte sedimentation rate, C-reactive protein, white blood cell counts, MPO concentration, and biomarkers of oxidative stress were measured before and after the infusion of infliximab. Patients with active disease showed increases in concentrations of MPO and biomarkers of oxidation, but decreases in antioxidant parameters. After infliximab treatment, both inflammatory parameters and MPO concentrations were normalized. In conclusion: (1) the MPO concentration is related to inflammatory activity and could play an important role in the maintenance and outbreak of oxidative stress present in these diseases, and (2) infliximab inhibits MPO concentration.

Original language	English (US)
Pages (from-to)	211-216
Number of pages	6
Journal	Pharmacology
Volume	83
Issue number	4
DOIs	https://doi.org/10.1159/000200022
State	Published - Apr 2009
Externally published	Yes

Keywords

Ankylosing spondylitis
Chronic inflammatory joint disease
Infliximab
Myeloperoxidase
Oxidative stress
Rheumatoid arthritis

ASJC Scopus subject areas

Pharmacology

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10.1159/000200022

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title = "Infliximab reduces myeloperoxidase concentration in chronic inflammatory joint diseases",

abstract = "The present study evaluated the effect of infliximab on the myeloperoxidase (MPO) concentration in chronic inflammatory joint disease. Eighteen patients were divided into active and inactive groups. Erythrocyte sedimentation rate, C-reactive protein, white blood cell counts, MPO concentration, and biomarkers of oxidative stress were measured before and after the infusion of infliximab. Patients with active disease showed increases in concentrations of MPO and biomarkers of oxidation, but decreases in antioxidant parameters. After infliximab treatment, both inflammatory parameters and MPO concentrations were normalized. In conclusion: (1) the MPO concentration is related to inflammatory activity and could play an important role in the maintenance and outbreak of oxidative stress present in these diseases, and (2) infliximab inhibits MPO concentration.",

keywords = "Ankylosing spondylitis, Chronic inflammatory joint disease, Infliximab, Myeloperoxidase, Oxidative stress, Rheumatoid arthritis",

author = "Montserrat Feij{\'o}o and Isaac T{\'u}nez and Inmaculada Tasset and Pedro Montilla and Ver{\'o}nica P{\'e}rez-Guijo and Elisa Mu{\~n}oz-Gomariz and Adela Ruiz and Ruxandra Schiotis and Eduardo Collantes",

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doi = "10.1159/000200022",

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volume = "83",

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T1 - Infliximab reduces myeloperoxidase concentration in chronic inflammatory joint diseases

AU - Feijóo, Montserrat

AU - Túnez, Isaac

AU - Tasset, Inmaculada

AU - Montilla, Pedro

AU - Pérez-Guijo, Verónica

AU - Muñoz-Gomariz, Elisa

AU - Ruiz, Adela

AU - Schiotis, Ruxandra

AU - Collantes, Eduardo

PY - 2009/4

Y1 - 2009/4

N2 - The present study evaluated the effect of infliximab on the myeloperoxidase (MPO) concentration in chronic inflammatory joint disease. Eighteen patients were divided into active and inactive groups. Erythrocyte sedimentation rate, C-reactive protein, white blood cell counts, MPO concentration, and biomarkers of oxidative stress were measured before and after the infusion of infliximab. Patients with active disease showed increases in concentrations of MPO and biomarkers of oxidation, but decreases in antioxidant parameters. After infliximab treatment, both inflammatory parameters and MPO concentrations were normalized. In conclusion: (1) the MPO concentration is related to inflammatory activity and could play an important role in the maintenance and outbreak of oxidative stress present in these diseases, and (2) infliximab inhibits MPO concentration.

AB - The present study evaluated the effect of infliximab on the myeloperoxidase (MPO) concentration in chronic inflammatory joint disease. Eighteen patients were divided into active and inactive groups. Erythrocyte sedimentation rate, C-reactive protein, white blood cell counts, MPO concentration, and biomarkers of oxidative stress were measured before and after the infusion of infliximab. Patients with active disease showed increases in concentrations of MPO and biomarkers of oxidation, but decreases in antioxidant parameters. After infliximab treatment, both inflammatory parameters and MPO concentrations were normalized. In conclusion: (1) the MPO concentration is related to inflammatory activity and could play an important role in the maintenance and outbreak of oxidative stress present in these diseases, and (2) infliximab inhibits MPO concentration.

KW - Ankylosing spondylitis

KW - Chronic inflammatory joint disease

KW - Infliximab

KW - Myeloperoxidase

KW - Oxidative stress

KW - Rheumatoid arthritis

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ER -

Infliximab reduces myeloperoxidase concentration in chronic inflammatory joint diseases

Abstract

Keywords

ASJC Scopus subject areas

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