Inflammatory myofibroblastic tumor of the liver inflammatory myofibroblastic tumor of the liver

Garron J. Solomon, Milan Kinkhabwala, Mohammed Akhtar

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We report a case of hepatic inflammatory myofibroblastic tumor in a 26-year-old African American man who presented with right upper quadrant pain, weight loss, and fatigue during the previous year. Hepatomegaly was found on physical examination. Laboratory findings were significant for mild normocytic, normochromic anemia and elevated erythrocyte sedimentation rate. Imaging studies showed 2 contiguous masses suspicious for malignancy. A left partial hepatectomy was performed; the preoperative differential diagnosis was for angiosarcoma and hepatocellular carcinoma. The resected liver specimen showed 2 contiguous, firm, tan-white nodules that microscopically represented a proliferation of spindled myofibroblast cells set in an inflammatory and collagenized background. The spindle cells were strongly reactive for smooth muscle actin but negative for ALK-1. The morphologic and immunophenotypic findings, coupled with the clinical presentation, were consistent with an inflammatory myofabroblastic tumor of the liver.

Original languageEnglish (US)
Pages (from-to)1548-1551
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number10
StatePublished - Oct 2006
Externally publishedYes

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Liver
Neoplasms
Hemangiosarcoma
Hepatomegaly
Myofibroblasts
Blood Sedimentation
Hepatectomy
African Americans
Physical Examination
Fatigue
Smooth Muscle
Actins
Anemia
Weight Loss
Hepatocellular Carcinoma
Differential Diagnosis
Pain

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Inflammatory myofibroblastic tumor of the liver inflammatory myofibroblastic tumor of the liver. / Solomon, Garron J.; Kinkhabwala, Milan; Akhtar, Mohammed.

In: Archives of Pathology and Laboratory Medicine, Vol. 130, No. 10, 10.2006, p. 1548-1551.

Research output: Contribution to journalArticle

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