Inflammatory monocyte effector mechanisms

Grégoire Lauvau, Laurent Chorro, Emily Spaulding, Saïdi M.Homa Soudja

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Monocytes are blood-derived mononuclear phagocytic cells that traffic throughout the body and can provide rapid innate immune effector responses in response to microbial pathogen infections. Among blood monocytes, the most abundant subset in mice is represented by inflammatory Ly6C+ CCR2+ monocytes and is the functional equivalent of the CD14+ monocytes in humans. Herein we focus on published evidence describing the exquisite functional plasticity of these cells, and we extend this overview to their multiples roles in vivo during host immune defenses against microbial pathogen infections, as antigen-presenting cells, inflammatory cells or Trojan horse cells.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalCellular Immunology
Volume291
Issue number1-2
DOIs
StatePublished - Sep 1 2014

Keywords

  • Antigen presentation
  • CCR2
  • Effector functions
  • Inflammatory Ly6C monocytes
  • Microbial pathogens

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Lauvau, G., Chorro, L., Spaulding, E., & Soudja, S. M. H. (2014). Inflammatory monocyte effector mechanisms. Cellular Immunology, 291(1-2), 32-40. https://doi.org/10.1016/j.cellimm.2014.07.007