TY - JOUR
T1 - Inflammatory biomarkers and motoric cognitive risk syndrome
T2 - Multicohort survey
AU - Groeger, Justina L.
AU - Ayers, Emmeline
AU - Barzilai, Nir
AU - Beauchet, Olivier
AU - Callisaya, Michele
AU - Torossian, Maral R.
AU - Derby, Carol
AU - Doi, Takehiko
AU - Lipton, Richard B.
AU - Milman, Sofiya
AU - Nakakubo, Sho
AU - Shimada, Hiroyuki
AU - Srikanth, Velandai
AU - Wang, Cuiling
AU - Verghese, Joe
N1 - Funding Information:
The research was supported by the National Institute On Aging (NIA) under award number 1R01AG057548–01A1 . Funding agencies for the participating cohorts are as follows. The Einstein Aging Study is funded by the NIH/ National Institute on Aging grant ( PO1 AG03949 ). The LonGenity study is supported by grants from the NIH (R01AG044829, P01AG021654, R01 AG 046,949, K23AG051148, the Nathan Shock Center of Excellence for the Biology of Aging P30AG038072, Glenn Center for the Biology of Human Aging Paul Glenn Foundation Grant, American Federation for Aging Research. The TASCOG study is support by the National Health and Medical Research Council Project Grants ( 403,000 ). The CCMA study is supported by grants from the NIH/NIA (R01AG036921; RO1AGO44007–01A1). The NCGG-SGS was supported by grants from the Japan Agency for Medical Research and Development ( 15dk0107003h0003 , 15dk020 7004h0203 ), JSPS KAKENHI Grant Number JP26242059 and Ministry of Health, Labour and Welfar (Research project on health and welfare promotion for the elderly).
Publisher Copyright:
© 2022
PY - 2022/1
Y1 - 2022/1
N2 - Background: Inflammation may play a role in Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome comprised of slow gait and cognitive complaints. Our objective was to examine associations of inflammatory biomarkers with MCR. Methods: We examined association of interleukin-6 (IL-6) and C-reactive protein (CRP) with prevalent MCR using logistic regression in 3,101 older adults (52% female) from five cohorts (National Center for Geriatrics & Gerontology Study of Geriatric Syndromes [NCGG-SGS], Central Control of Mobility in Aging [CCMA], Tasmanian Study of Cognition and Gait [TASCOG], LonGenity, and Einstein Aging Study [EAS]). Associations were reported as odds ratios adjusted for sex, age, education, depressive symptoms, body mass index, and vascular diseases (aOR) with 95% confidence intervals (CI). Meta-analysis and analyses stratified by vascular disease were also done. Results: Although associations between higher (worse) CRP and IL-6 tertiles and MCR were only seen in three out of the five cohorts (EAS, TASCOG, and LonGenity), when a pooled meta-analysis was performed, a robust association was demonstrated. In meta-analysis, highest tertiles of IL-6 (aOR 1.57, 95%CI 1.01- 2.44) and CRP (aOR 1.65, 95%CI 1.09–2.48) was associated with MCR versus lowest tertiles in the pooled sample. Higher CRP was associated with MCR among those with vascular disease in TASCOG and LonGenity cohorts, and among those without vascular disease in EAS. Conclusions: IL-6 and CRP levels are associated with MCR in older adults, and this association varies by presence of vascular disease.
AB - Background: Inflammation may play a role in Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome comprised of slow gait and cognitive complaints. Our objective was to examine associations of inflammatory biomarkers with MCR. Methods: We examined association of interleukin-6 (IL-6) and C-reactive protein (CRP) with prevalent MCR using logistic regression in 3,101 older adults (52% female) from five cohorts (National Center for Geriatrics & Gerontology Study of Geriatric Syndromes [NCGG-SGS], Central Control of Mobility in Aging [CCMA], Tasmanian Study of Cognition and Gait [TASCOG], LonGenity, and Einstein Aging Study [EAS]). Associations were reported as odds ratios adjusted for sex, age, education, depressive symptoms, body mass index, and vascular diseases (aOR) with 95% confidence intervals (CI). Meta-analysis and analyses stratified by vascular disease were also done. Results: Although associations between higher (worse) CRP and IL-6 tertiles and MCR were only seen in three out of the five cohorts (EAS, TASCOG, and LonGenity), when a pooled meta-analysis was performed, a robust association was demonstrated. In meta-analysis, highest tertiles of IL-6 (aOR 1.57, 95%CI 1.01- 2.44) and CRP (aOR 1.65, 95%CI 1.09–2.48) was associated with MCR versus lowest tertiles in the pooled sample. Higher CRP was associated with MCR among those with vascular disease in TASCOG and LonGenity cohorts, and among those without vascular disease in EAS. Conclusions: IL-6 and CRP levels are associated with MCR in older adults, and this association varies by presence of vascular disease.
KW - CRP
KW - IL-6
KW - Motoric cognitive risk syndrome
KW - Proinflammatory cytokines
KW - Vascular disease
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U2 - 10.1016/j.cccb.2022.100151
DO - 10.1016/j.cccb.2022.100151
M3 - Article
AN - SCOPUS:85139237676
SN - 2666-2450
VL - 3
JO - Cerebral Circulation - Cognition and Behavior
JF - Cerebral Circulation - Cognition and Behavior
M1 - 100151
ER -