Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract

Nicole C. Panarelli, Rhonda K. Yantiss

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Immune compromise may result from genetic abnormalities, HIV/AIDS, or consequences of therapy for neoplastic and autoimmune diseases. Many immunocompromised patients develop severe gastrointestinal symptoms, particularly diarrhea, accompanied by non-specific or mild endoscopic abnormalities; mucosal biopsy with pathologic interpretation has a major role in the diagnosis and management of these patients. Immunocompromised individuals are at risk for all the diseases that affect those with a healthy immune system, but they are also prone to other illnesses that rarely affect immunocompetent patients. This review discusses the gastrointestinal manifestations of primary and acquired immunodeficiency, chemotherapy-related injury, and infections that show a predilection for immunocompromised patients. Key histologic features and relevant differential diagnoses are emphasized.

Original languageEnglish (US)
Pages (from-to)844-861
Number of pages18
JournalModern Pathology
Issue number6
StatePublished - Jun 1 2018

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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