Inflammation in response to n3 fatty acids in a porcine obesity model

Richard J. Faris, Rebecca L. Boddicker, Jennifer Walker-Daniels, Jenny Li, Douglas E. Jones, Michael E. Spurlock

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fatty acids have distinct cellular effects related to inflammation and insulin sensitivity. Dietary saturated fat activates toll-like receptor 4, which in turn can lead to chronic inflammation, insulin resistance, and adipose tissue macrophage infiltration. Conversely, n3 fatty acids are generally antiinflammatory and promote insulin sensitivity, in part via peroxisome proliferator-activated receptor γ. Ossabaw swine are a useful biomedical model of obesity. We fed Ossabaw pigs either a low-fat control diet or a diet containing high-fat palm oil with or without additional n3 fatty acids for 30 wk to investigate the effect of saturated fats and n3 fatty acids on obesity-linked inflammatory markers. The diet did not influence the inflammatory markers C-reactive protein, TNFα, IL6, or IL12. In addition, n3 fatty acids attenuated the increase in inflammatory adipose tissue CD16 -CD14+ macrophages induced by high palm oil. High-fat diets with and without n3 fatty acids both induced hyperglycemia without hyperinsulinemia. The high-fat only group but not the high-fat group with n3 fatty acids showed reduced insulin sensitivity in response to insulin challenge. This effect was not mediated by decreased phosphorylation of protein kinase B. Therefore, in obese Ossabaw swine, n3 fatty acids partially attenuate insulin resistance but only marginally change inflammatory status and macrophage phenotype in adipose tissue.

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalComparative Medicine
Volume62
Issue number6
StatePublished - Dec 1 2012
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
obesity
Swine
Obesity
inflammation
Fats
Inflammation
fatty acids
Insulin Resistance
insulin resistance
swine
Insulin
Nutrition
Macrophages
Adipose Tissue
adipose tissue
High Fat Diet
macrophages
Tissue
palm oils

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Faris, R. J., Boddicker, R. L., Walker-Daniels, J., Li, J., Jones, D. E., & Spurlock, M. E. (2012). Inflammation in response to n3 fatty acids in a porcine obesity model. Comparative Medicine, 62(6), 495-503.

Inflammation in response to n3 fatty acids in a porcine obesity model. / Faris, Richard J.; Boddicker, Rebecca L.; Walker-Daniels, Jennifer; Li, Jenny; Jones, Douglas E.; Spurlock, Michael E.

In: Comparative Medicine, Vol. 62, No. 6, 01.12.2012, p. 495-503.

Research output: Contribution to journalArticle

Faris, RJ, Boddicker, RL, Walker-Daniels, J, Li, J, Jones, DE & Spurlock, ME 2012, 'Inflammation in response to n3 fatty acids in a porcine obesity model', Comparative Medicine, vol. 62, no. 6, pp. 495-503.
Faris RJ, Boddicker RL, Walker-Daniels J, Li J, Jones DE, Spurlock ME. Inflammation in response to n3 fatty acids in a porcine obesity model. Comparative Medicine. 2012 Dec 1;62(6):495-503.
Faris, Richard J. ; Boddicker, Rebecca L. ; Walker-Daniels, Jennifer ; Li, Jenny ; Jones, Douglas E. ; Spurlock, Michael E. / Inflammation in response to n3 fatty acids in a porcine obesity model. In: Comparative Medicine. 2012 ; Vol. 62, No. 6. pp. 495-503.
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