Inflammation in cardiac injury, repair and regeneration

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Purpose of review Cardiomyocyte necrosis activates an inflammatory response that serves to clear the injured myocardium from dead cells, and stimulates repair, but may also extend injury. This manuscript discusses new findings that advanced our understanding of the role of inflammation in cardiac injury and repair. Recent findings Recently published studies have identified interleukin-1α and RNA released by necrotic cardiomyocytes as key danger signals that trigger the inflammatory response following infarction. Interleukin-1 promotes activation of a proinflammatory phenotype in leukocytes and fibroblasts, and delays myofibroblast transdifferentiation. Inhibitory lymphocytes play a crucial role in negative regulation of the postinfarction inflammatory response by modulating macrophage and fibroblast phenotype. Cardiac macrophages exhibit significant heterogeneity and phenotypic plasticity and may orchestrate the reparative response following infarction. In neonatal mice, resident embryonic macrophage subpopulations may promote a regenerative response. In contrast, in adult animals replacement of resident macrophage populations with monocyte-derived macrophages may induce inflammation while inhibiting cardiac regeneration. These exciting observations highlight the crucial role of macrophages in cardiac injury and repair, but should be interpreted with caution considering the limitations of murine models of neonatal myocardial injury. Summary Design of novel strategies to reduce cardiac injury, improve repair and promote regeneration is dependent on understanding of the cell biology of the inflammatory response.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalCurrent Opinion in Cardiology
Volume30
Issue number3
DOIs
StatePublished - May 27 2015

Fingerprint

Regeneration
Macrophages
Inflammation
Wounds and Injuries
Interleukin-1
Cardiac Myocytes
Infarction
Fibroblasts
Phenotype
Myofibroblasts
Cell Biology
Myocardium
Leukocytes
Necrosis
Lymphocytes
RNA
Population

Keywords

  • cytokine
  • inflammation
  • lymphocyte
  • macrophage
  • myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Inflammation in cardiac injury, repair and regeneration. / Frangogiannis, Nikolaos G.

In: Current Opinion in Cardiology, Vol. 30, No. 3, 27.05.2015, p. 240-245.

Research output: Contribution to journalArticle

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