Infiltration of the sphenopalatine ganglion decreases blood pressure in newly diagnosed and never treated patients with essential hypertension

Helen Triantafyllidi, Chrysa Arvaniti, Leonidas Palaiodimos, Stefanos Vlachos, Antonios Schoinas, Chrysanthi Batistaki, Georgia Kostopanagiotou, John Lekakis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Sphenopalatine ganglion (SPG), an extracranial structure, is connected with the central nervous system (CNS) through sympathetic and parasympathetic nerves. We hypothesized that SPG block through sympathetic nerves anesthesia might decrease blood pressure (BP) in recently diagnosed and never treated middle-aged patients with essential hypertension. Methods We performed SBG block in 22 hypertensive patients (mean age 45 ± 12 years, 15 men). All patients have been subjected to 24 hour ambulatory blood pressure monitoring a week prior the procedure as well as in a period of 21–30 days after the SBG block in order to estimate differences in 24 h average systolic (24 h SBP) and diastolic blood pressure (24 h DBP), daytime, nighttime, pre-awake and early morning SBP and DBP as well as BP load. Results We found that 24 h SBP (p = 0.001) and 24 h DBP (p < 0.001), daytime SBP and DBP (p < 0.001) as well as daytime SBP and DBP load (p = 0.002 and p < 0.001, respectively) were decreased in total population at 21–30 days after SPG block. In 11/22 responders (24 h SBP decrease ≥ 5 mm Hg), SBP and DBP were reduced during overall 24 h and daytime (p < 0.001) and nighttime periods (p = 0.01 and p = 0.06, respectively) while pre-awake SBP (p = 0.09) along with daytime SBP and DBP load (p = 0.07 and p = 0.06, respectively) were also almost decreased. Conclusions SBG block might be a promising, non-invasive, safe, painless and easy to perform therapeutic option of BP decrease. As with renal denervation, SBG should be effective in those hypertensive patients with an activated SNS, so a period of patient selection should precede the application of this procedure.

Original languageEnglish (US)
Pages (from-to)345-351
Number of pages7
JournalInternational Journal of Cardiology
Volume223
DOIs
StatePublished - Nov 15 2016
Externally publishedYes

Fingerprint

Ganglia
Blood Pressure
Sphenopalatine Ganglion Block
Ambulatory Blood Pressure Monitoring
Denervation
Essential Hypertension
Patient Selection
Anesthesia
Central Nervous System
Kidney
Population

Keywords

  • 24 h blood pressure measurement (24 h ABPM)
  • Arterial hypertension
  • Neural block
  • Sphenopalatine ganglion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Infiltration of the sphenopalatine ganglion decreases blood pressure in newly diagnosed and never treated patients with essential hypertension. / Triantafyllidi, Helen; Arvaniti, Chrysa; Palaiodimos, Leonidas; Vlachos, Stefanos; Schoinas, Antonios; Batistaki, Chrysanthi; Kostopanagiotou, Georgia; Lekakis, John.

In: International Journal of Cardiology, Vol. 223, 15.11.2016, p. 345-351.

Research output: Contribution to journalArticle

Triantafyllidi, Helen ; Arvaniti, Chrysa ; Palaiodimos, Leonidas ; Vlachos, Stefanos ; Schoinas, Antonios ; Batistaki, Chrysanthi ; Kostopanagiotou, Georgia ; Lekakis, John. / Infiltration of the sphenopalatine ganglion decreases blood pressure in newly diagnosed and never treated patients with essential hypertension. In: International Journal of Cardiology. 2016 ; Vol. 223. pp. 345-351.
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abstract = "Background Sphenopalatine ganglion (SPG), an extracranial structure, is connected with the central nervous system (CNS) through sympathetic and parasympathetic nerves. We hypothesized that SPG block through sympathetic nerves anesthesia might decrease blood pressure (BP) in recently diagnosed and never treated middle-aged patients with essential hypertension. Methods We performed SBG block in 22 hypertensive patients (mean age 45 ± 12 years, 15 men). All patients have been subjected to 24 hour ambulatory blood pressure monitoring a week prior the procedure as well as in a period of 21–30 days after the SBG block in order to estimate differences in 24 h average systolic (24 h SBP) and diastolic blood pressure (24 h DBP), daytime, nighttime, pre-awake and early morning SBP and DBP as well as BP load. Results We found that 24 h SBP (p = 0.001) and 24 h DBP (p < 0.001), daytime SBP and DBP (p < 0.001) as well as daytime SBP and DBP load (p = 0.002 and p < 0.001, respectively) were decreased in total population at 21–30 days after SPG block. In 11/22 responders (24 h SBP decrease ≥ 5 mm Hg), SBP and DBP were reduced during overall 24 h and daytime (p < 0.001) and nighttime periods (p = 0.01 and p = 0.06, respectively) while pre-awake SBP (p = 0.09) along with daytime SBP and DBP load (p = 0.07 and p = 0.06, respectively) were also almost decreased. Conclusions SBG block might be a promising, non-invasive, safe, painless and easy to perform therapeutic option of BP decrease. As with renal denervation, SBG should be effective in those hypertensive patients with an activated SNS, so a period of patient selection should precede the application of this procedure.",
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AU - Triantafyllidi, Helen

AU - Arvaniti, Chrysa

AU - Palaiodimos, Leonidas

AU - Vlachos, Stefanos

AU - Schoinas, Antonios

AU - Batistaki, Chrysanthi

AU - Kostopanagiotou, Georgia

AU - Lekakis, John

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N2 - Background Sphenopalatine ganglion (SPG), an extracranial structure, is connected with the central nervous system (CNS) through sympathetic and parasympathetic nerves. We hypothesized that SPG block through sympathetic nerves anesthesia might decrease blood pressure (BP) in recently diagnosed and never treated middle-aged patients with essential hypertension. Methods We performed SBG block in 22 hypertensive patients (mean age 45 ± 12 years, 15 men). All patients have been subjected to 24 hour ambulatory blood pressure monitoring a week prior the procedure as well as in a period of 21–30 days after the SBG block in order to estimate differences in 24 h average systolic (24 h SBP) and diastolic blood pressure (24 h DBP), daytime, nighttime, pre-awake and early morning SBP and DBP as well as BP load. Results We found that 24 h SBP (p = 0.001) and 24 h DBP (p < 0.001), daytime SBP and DBP (p < 0.001) as well as daytime SBP and DBP load (p = 0.002 and p < 0.001, respectively) were decreased in total population at 21–30 days after SPG block. In 11/22 responders (24 h SBP decrease ≥ 5 mm Hg), SBP and DBP were reduced during overall 24 h and daytime (p < 0.001) and nighttime periods (p = 0.01 and p = 0.06, respectively) while pre-awake SBP (p = 0.09) along with daytime SBP and DBP load (p = 0.07 and p = 0.06, respectively) were also almost decreased. Conclusions SBG block might be a promising, non-invasive, safe, painless and easy to perform therapeutic option of BP decrease. As with renal denervation, SBG should be effective in those hypertensive patients with an activated SNS, so a period of patient selection should precede the application of this procedure.

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