Infertility: Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age

R. T. Scott, M. S. Opsahl, M. R. Leonardi, G. S. Neall, E. H. Illions, D. Navot

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

This study evaluated the impact of age and ovarian reserve status on cumulative pregnancy rates. Approximately 1200 women from a general infertile population underwent ovarian reserve screening with the clomiphene citrate challenge test in the first few months of their initial evaluation. All patients then underwent a thorough infertility evaluation with therapy appropriate for their specific diagnoses. Patients with evidence of tubal disease, peritoneal adhesive disease, or male factor were eliminated. The 588 remaining patients were evaluated based on their age and ovarian reserve status, and their long-term pregnancy rates were compared using life table analyses. There was a dramatic decrease in pregnancy rates associated with an abnormal clomiphene citrate challenge test which was uniformly poor independent of age. Patients with normal ovarian reserve had much higher pregnancy rates, but a significant age-related decline in pregnancy rates was clearly identified. We conclude that women with evidence of diminished ovarian reserve have uniformly poor pregnancy rates independent of their age, but that age remains an important prognostic factor among those with a normal ovarian reserve. The combined use of maternal age and ovarian reserve screening should be used when counselling individual patients regarding their long-term prognoses for conception.

Original languageEnglish (US)
Pages (from-to)1706-1710
Number of pages5
JournalHuman Reproduction
Volume10
Issue number7
StatePublished - Jul 1995
Externally publishedYes

Fingerprint

Life Table
Infertility
Life Tables
Pregnancy
Pregnancy Rate
Screening
Population
Adhesives
Clomiphene
Peritoneal Diseases
Prognostic Factors
Prognosis
Maternal Age
Evaluation
Ovarian Reserve
Life table
Therapy
Counseling
Decrease

Keywords

  • Clomiphene citrate
  • Maternal age
  • Ovarian reserve
  • Ovary
  • Pregnancy rates

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Rehabilitation
  • Developmental Biology
  • Physiology

Cite this

Scott, R. T., Opsahl, M. S., Leonardi, M. R., Neall, G. S., Illions, E. H., & Navot, D. (1995). Infertility: Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age. Human Reproduction, 10(7), 1706-1710.

Infertility : Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age. / Scott, R. T.; Opsahl, M. S.; Leonardi, M. R.; Neall, G. S.; Illions, E. H.; Navot, D.

In: Human Reproduction, Vol. 10, No. 7, 07.1995, p. 1706-1710.

Research output: Contribution to journalArticle

Scott, RT, Opsahl, MS, Leonardi, MR, Neall, GS, Illions, EH & Navot, D 1995, 'Infertility: Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age', Human Reproduction, vol. 10, no. 7, pp. 1706-1710.
Scott, R. T. ; Opsahl, M. S. ; Leonardi, M. R. ; Neall, G. S. ; Illions, E. H. ; Navot, D. / Infertility : Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age. In: Human Reproduction. 1995 ; Vol. 10, No. 7. pp. 1706-1710.
@article{bc4ab94749804f4e962ed06c0ef44d3f,
title = "Infertility: Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age",
abstract = "This study evaluated the impact of age and ovarian reserve status on cumulative pregnancy rates. Approximately 1200 women from a general infertile population underwent ovarian reserve screening with the clomiphene citrate challenge test in the first few months of their initial evaluation. All patients then underwent a thorough infertility evaluation with therapy appropriate for their specific diagnoses. Patients with evidence of tubal disease, peritoneal adhesive disease, or male factor were eliminated. The 588 remaining patients were evaluated based on their age and ovarian reserve status, and their long-term pregnancy rates were compared using life table analyses. There was a dramatic decrease in pregnancy rates associated with an abnormal clomiphene citrate challenge test which was uniformly poor independent of age. Patients with normal ovarian reserve had much higher pregnancy rates, but a significant age-related decline in pregnancy rates was clearly identified. We conclude that women with evidence of diminished ovarian reserve have uniformly poor pregnancy rates independent of their age, but that age remains an important prognostic factor among those with a normal ovarian reserve. The combined use of maternal age and ovarian reserve screening should be used when counselling individual patients regarding their long-term prognoses for conception.",
keywords = "Clomiphene citrate, Maternal age, Ovarian reserve, Ovary, Pregnancy rates",
author = "Scott, {R. T.} and Opsahl, {M. S.} and Leonardi, {M. R.} and Neall, {G. S.} and Illions, {E. H.} and D. Navot",
year = "1995",
month = "7",
language = "English (US)",
volume = "10",
pages = "1706--1710",
journal = "Human reproduction (Oxford, England)",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Infertility

T2 - Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age

AU - Scott, R. T.

AU - Opsahl, M. S.

AU - Leonardi, M. R.

AU - Neall, G. S.

AU - Illions, E. H.

AU - Navot, D.

PY - 1995/7

Y1 - 1995/7

N2 - This study evaluated the impact of age and ovarian reserve status on cumulative pregnancy rates. Approximately 1200 women from a general infertile population underwent ovarian reserve screening with the clomiphene citrate challenge test in the first few months of their initial evaluation. All patients then underwent a thorough infertility evaluation with therapy appropriate for their specific diagnoses. Patients with evidence of tubal disease, peritoneal adhesive disease, or male factor were eliminated. The 588 remaining patients were evaluated based on their age and ovarian reserve status, and their long-term pregnancy rates were compared using life table analyses. There was a dramatic decrease in pregnancy rates associated with an abnormal clomiphene citrate challenge test which was uniformly poor independent of age. Patients with normal ovarian reserve had much higher pregnancy rates, but a significant age-related decline in pregnancy rates was clearly identified. We conclude that women with evidence of diminished ovarian reserve have uniformly poor pregnancy rates independent of their age, but that age remains an important prognostic factor among those with a normal ovarian reserve. The combined use of maternal age and ovarian reserve screening should be used when counselling individual patients regarding their long-term prognoses for conception.

AB - This study evaluated the impact of age and ovarian reserve status on cumulative pregnancy rates. Approximately 1200 women from a general infertile population underwent ovarian reserve screening with the clomiphene citrate challenge test in the first few months of their initial evaluation. All patients then underwent a thorough infertility evaluation with therapy appropriate for their specific diagnoses. Patients with evidence of tubal disease, peritoneal adhesive disease, or male factor were eliminated. The 588 remaining patients were evaluated based on their age and ovarian reserve status, and their long-term pregnancy rates were compared using life table analyses. There was a dramatic decrease in pregnancy rates associated with an abnormal clomiphene citrate challenge test which was uniformly poor independent of age. Patients with normal ovarian reserve had much higher pregnancy rates, but a significant age-related decline in pregnancy rates was clearly identified. We conclude that women with evidence of diminished ovarian reserve have uniformly poor pregnancy rates independent of their age, but that age remains an important prognostic factor among those with a normal ovarian reserve. The combined use of maternal age and ovarian reserve screening should be used when counselling individual patients regarding their long-term prognoses for conception.

KW - Clomiphene citrate

KW - Maternal age

KW - Ovarian reserve

KW - Ovary

KW - Pregnancy rates

UR - http://www.scopus.com/inward/record.url?scp=0029142695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029142695&partnerID=8YFLogxK

M3 - Article

C2 - 8582965

AN - SCOPUS:0029142695

VL - 10

SP - 1706

EP - 1710

JO - Human reproduction (Oxford, England)

JF - Human reproduction (Oxford, England)

SN - 0268-1161

IS - 7

ER -