Infections and autoimmune endocrine disease

Yaron Tomer, Terry F. Davies

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The literature examined in this review points to the possible involvement of infectious agents in the pathogenesis of autoimmune endocrine diseases, primarily autoimmune thyroid disease and diabetes mellitus. Various mechanisms have been proposed to explain induction of autoimmunity by infection but it seems that three possibilities may be important in individuals susceptible to developing autoimmune disease: molecular mimicry (perhaps to retroviruses); polyclonal T cell activation (by an endogenous superantigen or an infecting organism); and MHC class II antigen induction. It seems reasonable that all three mechanisms operate together or separately in different individuals. Data continue to accumulate in favour of infectious agents being important initiators of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)47-70
Number of pages24
JournalBailliere's Clinical Endocrinology and Metabolism
Volume9
Issue number1
DOIs
StatePublished - Jan 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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