Infections and autoimmune endocrine disease

Yaron Tomer; Terry F. Davies

doi:10.1016/S0950-351X(95)80819-1

Infections and autoimmune endocrine disease

Yaron Tomer, Terry F. Davies

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The literature examined in this review points to the possible involvement of infectious agents in the pathogenesis of autoimmune endocrine diseases, primarily autoimmune thyroid disease and diabetes mellitus. Various mechanisms have been proposed to explain induction of autoimmunity by infection but it seems that three possibilities may be important in individuals susceptible to developing autoimmune disease: molecular mimicry (perhaps to retroviruses); polyclonal T cell activation (by an endogenous superantigen or an infecting organism); and MHC class II antigen induction. It seems reasonable that all three mechanisms operate together or separately in different individuals. Data continue to accumulate in favour of infectious agents being important initiators of autoimmune disease.

Original language	English (US)
Pages (from-to)	47-70
Number of pages	24
Journal	Bailliere's Clinical Endocrinology and Metabolism
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S0950-351X(95)80819-1
State	Published - Jan 1995
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0950-351X(95)80819-1

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Infections and autoimmune endocrine disease

Abstract

ASJC Scopus subject areas

UN SDGs

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