Infection with Human T-Cell Leukemia Virus Type I in Patients with Leukemia

Grace Y. Minamoto; Jonathan W.m. Gold; David A. Scheinberg; William D. Hardy; Nancy Chein; Evelyn Zuckerman; Lilian Reich; Kathleen Dietz; Timothy Gee; Jack Hoffer; Klaus Mayer; Janice Gabrilove; Bayard Clarkson; Donald Armstrong

doi:10.1056/NEJM198801283180405

Infection with Human T-Cell Leukemia Virus Type I in Patients with Leukemia

Grace Y. Minamoto, Jonathan W.m. Gold, David A. Scheinberg, William D. Hardy, Nancy Chein, Evelyn Zuckerman, Lilian Reich, Kathleen Dietz, Timothy Gee, Jack Hoffer, Klaus Mayer, Janice Gabrilove, Bayard Clarkson, Donald Armstrong

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Among 211 adults with leukemia who received multiple transfusions, 6 were found to be seropositive for human T-cell leukemia virus Type I (HTLV-I). Before the positive serum specimens were obtained, these patients received a mean of 14 units of red cells and 78 units of platelets. Seroconversion could be documented in three patients. None of the 6 patients seropositive for HTLV-I had a T-cell leukemia, other illnesses attributable to HTLV-I infection, or risk factors for HTLV-I infection other than transfusion: none were seropositive for human immunodeficiency virus. Patients with leukemia who receive multiple transfusions appear to be at risk for HTLV-I infection. (N Engl J Med 1988; 318: 219–22.)

Original language	English (US)
Pages (from-to)	219-222
Number of pages	4
Journal	New England Journal of Medicine
Volume	318
Issue number	4
DOIs	https://doi.org/10.1056/NEJM198801283180405
State	Published - Jan 28 1988
Externally published	Yes

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1056/NEJM198801283180405

Cite this

@article{11da6e5e84904a519eae268684c7550d,

title = "Infection with Human T-Cell Leukemia Virus Type I in Patients with Leukemia",

abstract = "Among 211 adults with leukemia who received multiple transfusions, 6 were found to be seropositive for human T-cell leukemia virus Type I (HTLV-I). Before the positive serum specimens were obtained, these patients received a mean of 14 units of red cells and 78 units of platelets. Seroconversion could be documented in three patients. None of the 6 patients seropositive for HTLV-I had a T-cell leukemia, other illnesses attributable to HTLV-I infection, or risk factors for HTLV-I infection other than transfusion: none were seropositive for human immunodeficiency virus. Patients with leukemia who receive multiple transfusions appear to be at risk for HTLV-I infection. (N Engl J Med 1988; 318: 219–22.)",

author = "Minamoto, {Grace Y.} and Gold, {Jonathan W.m.} and Scheinberg, {David A.} and Hardy, {William D.} and Nancy Chein and Evelyn Zuckerman and Lilian Reich and Kathleen Dietz and Timothy Gee and Jack Hoffer and Klaus Mayer and Janice Gabrilove and Bayard Clarkson and Donald Armstrong",

year = "1988",

month = jan,

day = "28",

doi = "10.1056/NEJM198801283180405",

language = "English (US)",

volume = "318",

pages = "219--222",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "4",

}

TY - JOUR

T1 - Infection with Human T-Cell Leukemia Virus Type I in Patients with Leukemia

AU - Minamoto, Grace Y.

AU - Gold, Jonathan W.m.

AU - Scheinberg, David A.

AU - Hardy, William D.

AU - Chein, Nancy

AU - Zuckerman, Evelyn

AU - Reich, Lilian

AU - Dietz, Kathleen

AU - Gee, Timothy

AU - Hoffer, Jack

AU - Mayer, Klaus

AU - Gabrilove, Janice

AU - Clarkson, Bayard

AU - Armstrong, Donald

PY - 1988/1/28

Y1 - 1988/1/28

N2 - Among 211 adults with leukemia who received multiple transfusions, 6 were found to be seropositive for human T-cell leukemia virus Type I (HTLV-I). Before the positive serum specimens were obtained, these patients received a mean of 14 units of red cells and 78 units of platelets. Seroconversion could be documented in three patients. None of the 6 patients seropositive for HTLV-I had a T-cell leukemia, other illnesses attributable to HTLV-I infection, or risk factors for HTLV-I infection other than transfusion: none were seropositive for human immunodeficiency virus. Patients with leukemia who receive multiple transfusions appear to be at risk for HTLV-I infection. (N Engl J Med 1988; 318: 219–22.)

AB - Among 211 adults with leukemia who received multiple transfusions, 6 were found to be seropositive for human T-cell leukemia virus Type I (HTLV-I). Before the positive serum specimens were obtained, these patients received a mean of 14 units of red cells and 78 units of platelets. Seroconversion could be documented in three patients. None of the 6 patients seropositive for HTLV-I had a T-cell leukemia, other illnesses attributable to HTLV-I infection, or risk factors for HTLV-I infection other than transfusion: none were seropositive for human immunodeficiency virus. Patients with leukemia who receive multiple transfusions appear to be at risk for HTLV-I infection. (N Engl J Med 1988; 318: 219–22.)

UR - http://www.scopus.com/inward/record.url?scp=0023864968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023864968&partnerID=8YFLogxK

U2 - 10.1056/NEJM198801283180405

DO - 10.1056/NEJM198801283180405

M3 - Article

C2 - 2892132

AN - SCOPUS:0023864968

SN - 0028-4793

VL - 318

SP - 219

EP - 222

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 4

ER -

Infection with Human T-Cell Leukemia Virus Type I in Patients with Leukemia

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this