Infection with Human T-Cell Leukemia Virus Type I in Patients with Leukemia

Grace Y. Minamoto, Jonathan W.m. Gold, David A. Scheinberg, William D. Hardy, Nancy Chein, Evelyn Zuckerman, Lilian Reich, Kathleen Dietz, Timothy Gee, Jack Hoffer, Klaus Mayer, Janice Gabrilove, Bayard Clarkson, Donald Armstrong

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Abstract

Among 211 adults with leukemia who received multiple transfusions, 6 were found to be seropositive for human T-cell leukemia virus Type I (HTLV-I). Before the positive serum specimens were obtained, these patients received a mean of 14 units of red cells and 78 units of platelets. Seroconversion could be documented in three patients. None of the 6 patients seropositive for HTLV-I had a T-cell leukemia, other illnesses attributable to HTLV-I infection, or risk factors for HTLV-I infection other than transfusion: none were seropositive for human immunodeficiency virus. Patients with leukemia who receive multiple transfusions appear to be at risk for HTLV-I infection. (N Engl J Med 1988; 318: 219–22.)

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalNew England Journal of Medicine
Volume318
Issue number4
DOIs
Publication statusPublished - Jan 28 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Minamoto, G. Y., Gold, J. W. M., Scheinberg, D. A., Hardy, W. D., Chein, N., Zuckerman, E., ... Armstrong, D. (1988). Infection with Human T-Cell Leukemia Virus Type I in Patients with Leukemia. New England Journal of Medicine, 318(4), 219-222. https://doi.org/10.1056/NEJM198801283180405