Infection of mice with aerosolized Mycobacterium tuberculosis

Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility

J. Reid Schwebach, Bing Chen, Aharona Glatman-Freedman, Arturo Casadevall, John D. McKinney, John L. Harb, Patrick J. McGuire, W. Emmett Barkley, Barry R. Bloom, William R. Jacobs

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (

Original languageEnglish (US)
Pages (from-to)4646-4649
Number of pages4
JournalApplied and Environmental Microbiology
Volume68
Issue number9
DOIs
StatePublished - Sep 2002

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Facility Design and Construction
tuberculosis
Mycobacterium tuberculosis
aerosols
Nose
inoculum
safety
Safety
mice
dosage
Infection
Aerosols
infection
aerosol
methodology
dose

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biotechnology
  • Microbiology

Cite this

Infection of mice with aerosolized Mycobacterium tuberculosis : Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility. / Schwebach, J. Reid; Chen, Bing; Glatman-Freedman, Aharona; Casadevall, Arturo; McKinney, John D.; Harb, John L.; McGuire, Patrick J.; Barkley, W. Emmett; Bloom, Barry R.; Jacobs, William R.

In: Applied and Environmental Microbiology, Vol. 68, No. 9, 09.2002, p. 4646-4649.

Research output: Contribution to journalArticle

Schwebach, J. Reid ; Chen, Bing ; Glatman-Freedman, Aharona ; Casadevall, Arturo ; McKinney, John D. ; Harb, John L. ; McGuire, Patrick J. ; Barkley, W. Emmett ; Bloom, Barry R. ; Jacobs, William R. / Infection of mice with aerosolized Mycobacterium tuberculosis : Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility. In: Applied and Environmental Microbiology. 2002 ; Vol. 68, No. 9. pp. 4646-4649.
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