Infantile status epilepticus and future seizure susceptibility in the rat

Reiko Okada, Solomon L. Moshé, Bruce J. Albala

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The long-term effects of infantile seizures on the development of seizures in adulthood were studied in rats. Infantile seizures of varying severity were induced with intraperitoneal injections of kainic acid in 15-day-old rats. In adulthood the seizure susceptibility of the rats was determined by kindling the left amygdala and by measuring their ability to resist recurrent seizures. The results suggest that infantile status epilepticus is associated with a very high mortality; however in the surviving rats, infantile seizures even as severe as status epilepticus do not cause neuronal brain damage and do not predispose to the development of convulsions later in life.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalDevelopmental Brain Research
Volume15
Issue number2
DOIs
StatePublished - Aug 1984

Keywords

  • animal newborn
  • epilepsy
  • hippocampal sclerosis
  • kainic acid
  • kindling
  • rats
  • seizures
  • status epilepticus

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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